Development of a Paper-Based Microfluidic System for a Continuous High-Flow-Rate Fluid Manipulation

Naseri, Mahdi; Simon, George P.; Batchelor, Warren

doi:10.1021/acs.analchem.0c01003

Cited by 18 publications

(8 citation statements)

References 54 publications

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“…Recently, a paper-based inertial microfluidics that does not cause environmental pollution was successfully developed at a very low cost. 143 Unlike traditional paper microfluidics that use capillary force to pump and transfer the sample liquid, 144 paper-based inertial microfluidics can be operated at a high flow-rate throughput and can realize particle enrichment. It is noteworthy that the spiral channel can be constructed to focus and fractionate cells by rolling the “off-the-shelf” microbore tubing.…”

Section: Rapid Prototyping For Mass Manufacturing and Creating Novel ...mentioning

confidence: 99%

Inertial microfluidics: current status, challenges, and future opportunities

Xiang

Zhang

2022

Lab Chip

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Section: Rapid Prototyping For Mass Manufacturing and Creating Novel ...mentioning

confidence: 99%

Inertial microfluidics: current status, challenges, and future opportunities

Xiang

Zhang

2022

Lab Chip

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“…Due to its importance, the addition of disposability to the current ASSURED is proposed to consider the letter ‘D’ as the representative of ‘Deliverable and Disposable’. To be a disposable test, it should be made from disposable materials, among which cellulose is ideal as it can be disposed of without major environmental concerns, or can be readily incinerated if contaminated 70 …”

Section: Assured: a Closer Lookmentioning

confidence: 99%

“…These patterns are often created by printing the hydrophobic materials such as wax, to enclose the sample flow and lead it at desired directions 92 . The flow can be generated in these devices through the wicking properties of cellulose fibres 93,94 or by conventional syringe pumps 70 . The developed test could detect the MERS‐CoV RNA with a limit of detection (LoD) of 1.53 nM.…”

Section: Assured‐compliant Poc Tests For the Diagnosis Of Viral Infec...mentioning

confidence: 99%

ASSURED‐compliant point‐of‐care diagnostics for the detection of human viral infections

Naseri

Ziora

Simon

et al. 2021

Reviews in Medical Virology

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Viral disease outbreaks have been always a threat to global public health making affordable, rapid and accurate diagnostics highly important tools to slow down the spread of viruses and decrease the mortality rate. Point‐of‐care (POC) diagnostics have emerged as a strong tool for the diagnosis of viral infections, especially in countries where health‐care systems are inadequate to provide proper services to all citizens. According to the World Health Organization, an ideal POC diagnostic must be Affordable, Sensitive, Specific, User‐friendly, Rapid/Robust, Equipment‐free and Deliverable (ASSURED). This review surveys carefully each ASSURED criterion and identifies where existing viral POC diagnostics fail to meet these criteria. Given the widespread concern with plastic pollution, we also propose the addition of 'disposability' to the existing ASSURED criteria and consider the letter “D” as the representative of both Deliverable and Disposable. Next, the POC tests used for the diagnosis of several common human viral infections which met all the ASSURED criteria (ASSURED‐compliant) are described in detail. Finally, the future of ASSURED‐compliant POC diagnostics, capable of generating comparable results to the viral diagnostic gold standards, is discussed.

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“…43 These paper-based devices are ideal for remote locations, where access to critical medical resources is limited. 10,16,44 Several approaches have been developed for fabricating paper-based microfluidic devices 31,32,[45][46][47][48] such as photolithography, 49 inkjet printing, 50 flexography, 51 screen-printing, 52,53 laser cutting/pattering, [54][55][56] and plotting. 57,58 Each of these approaches offers a unique combination of resolution, cost, and ease of fabrication.…”

Section: Introductionmentioning

confidence: 99%

Increasing the packing density of assays in paper-based microfluidic devices

et al. 2021

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Paper-based devices have a wide range of applications in point-of-care diagnostics, environmental analysis, and food monitoring. Paper-based devices can be deployed to resource-limited countries and remote settings in developed countries. Paper-based point-of-care devices can provide access to diagnostic assays without significant user training to perform the tests accurately and timely. The market penetration of paper-based assays requires decreased device fabrication costs, including larger packing density of assays (i.e., closely packed features) and minimization of assay reagents. In this review, we discuss fabrication methods that allow for increasing packing density and generating closely packed features in paper-based devices. To ensure that the paper-based device is low-cost, advanced fabrication methods have been developed for the mass production of closely packed assays. These emerging methods will enable minimizing the volume of required samples (e.g., liquid biopsies) and reagents in paper-based microfluidic devices.

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Development of a Paper-Based Microfluidic System for a Continuous High-Flow-Rate Fluid Manipulation

Cited by 18 publications

References 54 publications

Inertial microfluidics: current status, challenges, and future opportunities

Inertial microfluidics: current status, challenges, and future opportunities

ASSURED‐compliant point‐of‐care diagnostics for the detection of human viral infections

Increasing the packing density of assays in paper-based microfluidic devices

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