Development of a photoresponsive chitosan conjugated prodrug nano-carrier for controlled delivery of antitumor drug 5-fluorouracil

Horo, Himali; Das, Soumi; Mandal, Bishnupada; Kundu, Lal Mohan

doi:10.1016/j.ijbiomac.2018.10.095

Cited by 40 publications

(10 citation statements)

References 31 publications

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“…Reproduced with permission. [217] Copyright 2019, Elsevier. carboxyl-modified Fe 3 O 4 NPs and positively charged poly(Llysine) through electrostatic interaction, Gao et al constructed a polypeptide-based nano-vehicle which fulfilled the combined antitumor treatment by released Pt drug and generated sufficient • OH, meanwhile used for T 2 -weighted MRI of tumor.…”

Section: Polypeptide-drug Conjugatesmentioning

confidence: 99%

“…[ 216 ] The amine terminal of CS is readily to react with carboxylic acid group, hence Horo et conjugated 5‐fluorouracil(5‐FU) to CS through photocleavable linker containing o ‐nitrobezyl analogue, then the conjugate prodrug was treated with sodium tripolyphosphate and formed into controlled released NPs upon irradiating with λ = 365 nm light (Figure 14E ). [ 217 ] To improve the loading efficacy of hydrophilic 5‐FU, its lipophilic prodrug 5‐FU‐stearic acid was synthesized and encapsulated into the core of xylan‐SA NPs through hydrophobic interaction. [ 218 ]…”

Section: Biomacromolecule‐drug Conjugatesmentioning

confidence: 99%

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Nanoparticulation of Prodrug into Medicines for Cancer Therapy

et al. 2021

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This article provides a broad spectrum about the nanoprodrug fabrication advances co-driven by prodrug and nanotechnology development to potentiate cancer treatment. The nanoprodrug inherits the features of both prodrug concept and nanomedicine know-how, attempts to solve underexploited challenge in cancer treatment cooperatively. Prodrugs can release bioactive drugs on-demand at specific sites to reduce systemic toxicity, this is done by using the special properties of the tumor microenvironment, such as pH value, glutathione concentration, and specific overexpressed enzymes; or by using exogenous stimulation, such as light, heat, and ultrasound. The nanotechnology, manipulating the matter within nanoscale, has high relevance to certain biological conditions, and has been widely utilized in cancer therapy. Together, the marriage of prodrug strategy which shield the side effects of parent drug and nanotechnology with pinpoint delivery capability has conceived highly camouflaged Trojan horse to maneuver cancerous threats.

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Section: Polypeptide-drug Conjugatesmentioning

confidence: 99%

Section: Biomacromolecule‐drug Conjugatesmentioning

confidence: 99%

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

et al. 2021

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“…While most polar drugs do not access cell membranes, nanomaterials can help solving this problem because of their high surface-to-volume ratio and low density. Furthermore, the small size, high stability and easily suitable surface modification properties of these nanomaterials also encourage their use as drug carriers ( Al-Musawi et al, 2019 ; Horo et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Binding mechanism and SERS spectra of 5-fluorouracil on gold clusters

2022

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The adsorption behaviour of the 5-fluorouracil (5FU) on small gold clusters AuN with N = 6, 8, 20 was evaluated by means of density functional theory using the PBE-D3 functional in combination with a mixed basis set, i.e. cc-pVDZ-PP for gold atoms and cc-pVTZ for non-metal elements. The binding energies between 5FU and gold clusters were determined in the range of 16–24 and 11–19 kcal/mol in gas-phase and aqueous media, respectively. The corresponding Gibbs energies were found to be around -7 to -10 kcal/mol in vacum and sigificantly reduced to -1 to -6 kcal/mol in water solution, indicating that both the association and dissociation processes are likely spontaneous. An analysis on the charge density difference tends to confirm the existence of a charge transfer from the 5FU molecule to Au atoms. Analysis of the surface-enhanced Raman scattering (SERS) spectra of 5FU adsorbed on the Au surfaces shows that the stretching vibrations of N−H and C=O bonds play a major role in the SERS phenomenon. A mechanism for the drug releasing from the gold surfaces is also proposed. The process is triggered by either the low pH in cancerous tumors or the presence of cysteine residues in protein matrices.

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“…In vivo analysis in mouse models with colon cancer displayed that the group treated with solid lipid nanoparticles loaded with 5‐Fu showed a better therapeutic outcome in comparison to 5‐Fu treated mice 15 . Several other types of 5‐Fu delivery systems based on biopolymers, 16 hydrogels, 17 imprinted polymers, 18 protein‐based nanoparticles, 19 and mesoporous silica 20 were also applied successfully.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

et al. 2022

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In this study, amino-functionalized mesoporous silica (MS) particles were synthesized and loaded with the anticancer drug, 5-Fu. In a post-modification reaction, the pores were gated by an azobenzene derivative to act as an enzyme-responsive drug delivery system. The synthesis and characterization of the MS structure were validated using various instrumental techniques such as XRD, N 2 adsorption/desorption, and FE-SEM and TEM. The loading efficiency and capacity of 5-Fu adsorption onto MS were evaluated; the adsorption isotherm graphs were plotted. The enzyme responsiveness feature of this nanocarrier was tested in the 5-Fu release study. The 5-Fu release from MS and the azo-capped compound was measured, and when sodium dithionite was used as a reducing agent and an azoreductase enzyme mimicker, the controlled release was observed. Finally, the cytotoxicity of 5-Fu loaded and azocapped MS in normal medium and sodium dithionate-containing medium was evaluated and compared with the cytotoxicity of the free drug.

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Development of a photoresponsive chitosan conjugated prodrug nano-carrier for controlled delivery of antitumor drug 5-fluorouracil

Cited by 40 publications

References 31 publications

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Binding mechanism and SERS spectra of 5-fluorouracil on gold clusters

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

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