Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration

Abstract

Nanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranesbased drug delivery systems to be used as wound dressings.

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

“…This composite nanofiber is a convenient and efficient low-cost method, which is important for wound antimicrobial as well as further drug delivery. Sequeira et al [ 142 ] prepared electrospun nanofibers by co-blending PVA and lysine, and also blended the anti-inflammatory agent ibuprofen (IBP) and antimicrobial agent lavender oil (LO) into the electrospun membrane by mixed electrospinning and surface physical adsorption methods. It was able to achieve sustained release of IBU and initial burst release of LO, as shown in Figure 9 C, which is important for initial antimicrobial and sustained anti-inflammatory in the healing process of wounds.…”

Electrospun Biomaterials in the Treatment and Prevention of Scars in Skin Wound Healing

“…A historic but still pertinent avenue for the treatment of wounds and scars is the use of essential oils (Sequeira et al, 2019). Previous research as developed electrospun nanofibers composed of alginate/polyethylene glycol (PEO) infused with lavender essential oil, for the treatment of UV-induced skin burns.…”

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

“…b The drug loading in the nanoparticles (NPs) (w/w%) is a theoretical value calculated according to the electrospraying conditions. Because electrospraying is essentially a physical drying process and tamoxifen citrate (TAM) has a boiling point of 140-144 • C without sublimation property, the drug encapsulation efficiency can be regarded as 100% [27,46].…”

“…However, they often comprise time-consuming and multiple-step processes and, thus, often have the difficulties of production on a large scale [22]. In comparison, the top-down routes (such as electrospinning and electrospraying) hold the fine promises for creating nanoproducts in a single-step manner and on a large scale [23][24][25][26][27][28][29][30][31][32] and, thus, they should provide new strategies for implementing nanocoating on solid medicated nanoparticles [33][34][35][36][37].…”