Development of a Preclinical Tool for Measuring Percutaneous Transfer of Dihydrogen, with a View to Optimizing Medical Devices Adapted to Focal Therapies in Dermatology

Salomez-Ihl, C.; Tanguy, S.; Boucher, F.; Pascal Mousselard, V.; Bedouch, P.; Stephanou, A.; Alcaraz, J. P.; Cinquin, P.

doi:10.1007/978-3-031-47375-3_23

Advances in Biochemistry in Health and Disease

2024

DOI: 10.1007/978-3-031-47375-3_23

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Development of a Preclinical Tool for Measuring Percutaneous Transfer of Dihydrogen, with a View to Optimizing Medical Devices Adapted to Focal Therapies in Dermatology

C. Salomez-Ihl,

S. Tanguy,

F. Boucher

et al.

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2024

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An ethically guided preclinical device for phenotyping H₂ production in laboratory rodents

Pascal‐Moussellard,

Boucher,

Tanguy

et al. 2024

Anim Models and Exp Med

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BackgroundDihydrogen (H2) is produced endogenously by the intestinal microbiota through the fermentation of diet carbohydrates. Over the past few years, numerous studies have demonstrated the significant therapeutic potential of H2 in various pathophysiological contexts, making the characterization of its production in laboratory species of major preclinical importance.MethodsThis study proposes an innovative solution to accurately monitor H2 production in free‐moving rodents while respecting animal welfare standards. The developed device consisted of a wire rodent cage placed inside an airtight chamber in which the air quality was maintained, and the H2 concentration was continuously analyzed. After the airtightness and efficiency of the systems used to control and maintain air quality in the chamber were checked, tests were carried out on rats and mice with different metabolic phenotypes, over 12 min to 1‐h experiments and repeatedly. H2 production rates (HPR) were obtained using an easy calculation algorithm based on a first‐order moving average.ResultsHPR in hyperphagic Zucker rats was found to be twice as high as in control Wistar rats, respectively, 2.64 and 1.27 nmol.s−1 per animal. In addition, the ingestion of inulin, a dietary fiber, stimulated H2 production in mice. HPRs were 0.46 nmol.s−1 for animals under control diet and 1.99 nmol.s−1 for animals under inulin diet.ConclusionsThe proposed device coupled with our algorithm enables fine analysis of the metabolic phenotype of laboratory rats or mice with regard to their endogenous H2 production.

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An ethically guided preclinical device for phenotyping H₂ production in laboratory rodents

Pascal‐Moussellard,

Boucher,

Tanguy

et al. 2024

Anim Models and Exp Med

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show abstract

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Development of a Preclinical Tool for Measuring Percutaneous Transfer of Dihydrogen, with a View to Optimizing Medical Devices Adapted to Focal Therapies in Dermatology

Cited by 1 publication

References 33 publications

An ethically guided preclinical device for phenotyping H₂ production in laboratory rodents

An ethically guided preclinical device for phenotyping H₂ production in laboratory rodents

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Development of a Preclinical Tool for Measuring Percutaneous Transfer of Dihydrogen, with a View to Optimizing Medical Devices Adapted to Focal Therapies in Dermatology

Cited by 1 publication

References 33 publications

An ethically guided preclinical device for phenotyping H2 production in laboratory rodents

An ethically guided preclinical device for phenotyping H2 production in laboratory rodents

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Product

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An ethically guided preclinical device for phenotyping H₂ production in laboratory rodents

An ethically guided preclinical device for phenotyping H₂ production in laboratory rodents