Development of a Proton Computed Tomography system for pre-clinical tests

Civinini, C.; Brianzi, M.; Bruzzi, M.; Bucciolini, M.; Carpinelli, M.; Cirrone, G.A.P.; Cuttone, G.; Presti, D. Lo; Pallotta, S.; Pugliatti, C.; Randazzo, N.; Romano, F.; Scaringella, M.; Sipala, V.; Stancampiano, C.; Talamonti, Cinzia; Tesi, M.; Vanzi, E.; Zani, M.

doi:10.1109/nssmic.2012.6551313

Cited by 3 publications

(3 citation statements)

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“…The impact of the material budget of the trackers was evaluated, specifically for silicon detectors (Civinini et al 2012, Sadrozinski et al 2013. The first study advocates a reduction of the downstream inner tracker thickness from 400 µm to 200 µm; the second concludes that increasing the tracker thickness from 200 µm to 320 µm has little impact on the error in the MLP, if the distance between the inner trackers and the object is neglected.…”

Section: Introductionmentioning

confidence: 99%

The impact of tracking system properties on the most likely path estimation in proton CT

Bopp¹,

Rescigno²,

Rousseau³

et al. 2014

Phys. Med. Biol.

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Proton CT nowadays aims at improving hadron therapy treatment planning by mapping the stopping power of materials. In order to optimize a spatial resolution of the reconstructed images, the most likely path (MLP) of each proton can be computed. We investigated the errors in the computation of this path due to the configuration of the system, i.e. the spatial resolution of the tracking planes, their material budget, and their positioning. A method for computing the uncertainty in the estimated paths for a given system was derived. The uncertainties upon the entrance and exit of the object were propagated analytically in the path computation. This procedure was then used to evaluate the impact of each parameter, and to compare different systems. We show that the intrinsic characteristics of the system generate an uncertainty in the positions and directions of the particles propagated during the MLP computation. The spatial resolution and material budget of the trackers in particular may affect the path estimation, and thus the spatial resolution of an image.

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Section: Introductionmentioning

confidence: 99%

The impact of tracking system properties on the most likely path estimation in proton CT

Bopp¹,

Rescigno²,

Rousseau³

et al. 2014

Phys. Med. Biol.

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“…Present state-of-the-art pCT prototypes made excellent advancements in the field, but they still show some limitations for a practical implementation. The custom-made technologies typically used (micro-strips [12], [13], scintillating fibers [14], and gas detectors [15]) limit their convenient application in commercial systems or they are undesirable in a hospital environment (due to the use of detectors and/or high voltages). In addition, the above-mentioned pCT prototypes are limited in terms of data acquisition speed, so that they all require exposure times of the order of many minutes, too long for a practical implementation of the technique [4] due to the inevitable movements of the patient (breathing) and discomfort over such long period.…”

Section: Proton Computed Tomographymentioning

confidence: 99%

“…The most recent studies report how radiation treatment using protons ( 1 H) and carbon ions ( 12 C) leads to improvements in treatment of many cancer types [1]. Modern superconducting cyclotrons are compact machines and make possible the acceleration of protons up to 250 MeV/u and 12 C ions up to about 500 MeV/u, enabling the practical realization of hadron therapy facilities worldwide [2]. Hadron therapy is in the process of joining the already established X-ray therapy as an effective radiation therapy to treat cancer disease.…”

Section: Introductionmentioning

confidence: 99%

iMPACT: An Innovative Tracker and Calorimeter for Proton Computed Tomography

Baruffaldi

Iuppa

Snoeys

2018

IEEE Trans. Radiat. Plasma Med. Sci.

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This contribution describes the first results obtained within the iMPACT project, which aims to build a novel proton computed-tomography (pCT) scanner for protons of energy up to 230 MeV, as used in hadron therapy. The iMPACT pCT scanner will improve the current state-of-the-art in proton tracking at all levels: speed, spatial resolution, material budget, and cost. We will first describe the design of the iMPACT scanner, which is composed by a tracker and a range calorimeter. We will then illustrate the results of a test with the ALPIDE sensor, a monolithic active pixels sensor, developed by the ALICE collaboration, which will equip the iMPACT tracker in this first phase. We finally detail the characterization building elements of the prototype of the range calorimeter, which is composed of segmented scintillator fingers readout by SiPMs. Reported beam-test data will highlight how the technological choices we made well address the performances of a state-of-the-art pCT system.

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