Shock wave boundary/layer interactions (SWBLIs) are critical in high-speed aerodynamic flows, particularly within supersonic regimes, where unsteady dynamics can induce structural fatigue and degrade vehicle performance. Conventional measurement techniques, such as pressure-sensitive paint (PSP), face limitations in frequency response, calibration complexity, and intrusive instrumentation. Similarly, MEMS-based sensors, like Kulite® sensors, present challenges in terms of intrusiveness, cost, and integration complexity. This study presents a flexible, lightweight polyvinylidene fluoride (PVDF) piezoelectric sensor array designed for high-resolution wall-pressure measurements in SWBLI research. The primary objective is to optimize low-frequency pressure fluctuation detection, addressing SWBLI’s need for accurate, real-time measurements of low-frequency unsteadiness. Fabricated using a double-sided screen-printing technique, this sensor array is low-cost, flexible, and provides stable, high-sensitivity data. Finite Element Method (FEM) simulations indicate that the sensor structure also has potential for high-frequency responses, behaving as a high-pass filter with minimal signal attenuation up to 300 kHz, although the current study’s experimental testing is focused on low-frequency calibration and validation. A custom low-frequency sound pressure setup was used to calibrate the PVDF sensor array, ensuring uniform pressure distribution across sensor elements. Wind tunnel tests at Mach 2 verified the PVDF sensor’s ability to capture pressure fluctuations and unsteady behaviors consistent with those recorded by Kulite sensors. The findings suggest that PVDF sensors are promising alternatives for capturing low-frequency disturbances and intricate flow structures in advanced aerodynamic research, with high-frequency performance to be further explored in future work.