Development of a recombinant anti-VEGFR2-EPCAM bispecific antibody to improve antiangiogenic efficiency

Barzaman, Khadijeh; Samadi, Mitra; Moradi‐Kalbolandi, Shima; Majidzadeh‐A, Keivan; Salehi, Mina; Jalili, Neda; Jazayeri, Mir Hadi; Khorammi, Samaneh; Darvishi, Behrad; Siavashi, Vahid; Shekarabi, Mahdi; Farahmand, Leila

doi:10.1016/j.yexcr.2021.112685

Cited by 9 publications

(12 citation statements)

References 53 publications

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“…Immunotherapy is one of the newest strategies used in BC. Since there are some specific problems and complexity with other strategies of BC therapy (such as chemotherapy, radiotherapy, and surgery), the need for a new strategy made researchers propose immunotherapy [ 57 , 58 ]. Different immunotherapy methods, including mAb, vaccine, chimeric antigen receptor (CAR) T cells, have been investigated in BC.…”

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

“…CAR T cells are T cells engineered TCR and are one of the immunotherapy strategies [ 58 ]. Because T cells play a central role in the immune system, using them in cancer therapy is an interesting research area.…”

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

“…Using single-agent immunotherapy achieved success in BC; however, problems such as resistance appear [ 58 ]. To target cancer more effectively, combining different immunotherapy agents with distinct targets could be more useful [ 58 ]. In BC targeting, PD-1 and CTLA-4 by mAbs were approved by the US Food and Drug Administration [ 57 , 58 ].…”

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

“…To target cancer more effectively, combining different immunotherapy agents with distinct targets could be more useful [ 58 ]. In BC targeting, PD-1 and CTLA-4 by mAbs were approved by the US Food and Drug Administration [ 57 , 58 ]. Considering the fact that MUC-1 has been examined in immunotherapy lately, MUC-1 has been introduced to the combination immunotherapy field in BC.…”

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

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Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

et al. 2022

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Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs.

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Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

Section: The Role Of Muc-1 In Cancer Immunotherapymentioning

confidence: 99%

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Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

et al. 2022

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“…Moreover, failure in induction of apoptosis, as a consequence of aberrant expression of antigens, secreted angiogenic growth factors, or their receptors has already been linked to an elevated risk of metastasis, promotion of angiogenesis and an accelerated risk of resistance development to anti‐angiogenic cancer therapies. 21 , 22 , 23 , 24 , 25 , 26 , 27 Either mediated by the extrinsic (mediated by FASL, TNFα and so on) or intrinsic pathway (most importantly, accumulation of ROS and development of oxidative stress), the rest of the process will be followed by modulation of specific sets of procaspase molecules cleavage (caspase 8 and caspase 9 for extrinsic and intrinsic pathways respectively), ending in degradation of numerous intracellular target proteins, blebbing of cellular membrane, cleavage and degradation of chromosomal DNA, and finally, getting phagocytosed and scavenged by polymorphonuclear cells. 28 Apoptosis can be triggered upon activation of two main pathways which are broadly referred as “intrinsic” and “extrinsic” pathways.…”

Section: Apoptosis and Elf‐emf Exposurementioning

confidence: 99%

Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

et al. 2021

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In modern world, electromagnetic fields (EMFs) have become an inseparable part of routine life. Numerous electric power-generating human-made devices are now producing EMFs which are overlaid on those of earth's magnetic field. EMFs are usually identified with a 50 or 60 Hz frequency and therefore are classified under the extremely low-frequency, non-ionizing span of electromagnetic spectrum. 1 Due to these physical characteristics, ELF-EMFs are not capable of breaking molecular bond or inducing thermal effects on tissue. However, it is now proven that they can interact with human tissues and induce some weak electrical currents. 2 In addition, it is not completely understood whether biological effects induced by EMFs are hazardous for human or environment. During last few decades, a number of studies have reported beneficial effects of ELF-EMFs in treatment of cancer both in vitro and in vivo. [3][4][5][6][7] Despite this, the exact mechanism of these anti-neoplastic effects has not been confirmed yet.

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Endocannabinoids and related compounds as modulators of angiogenesis: Concepts and clinical significance

Afshar

Abbasinazari

Amin

et al. 2022

Cell Biochemistry & Function

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Vasculogenesis (the process of differentiation of angioblasts toward endothelial cells and de novo formation of crude vascular networks) and angiogenesis (the process of harmonized sprouting and dispersal of new capillaries from previously existing ones) are two fundamentally complementary processes, obligatory for maintaining physiological functioning of vascular system. In clinical practice, however, the later one is of more importance as it guarantees correct embryonic nourishment, accelerates wound healing processes, prevents uncontrolled cell growth and tumorigenesis, contributes in supplying nutritional demand following occlusion of coronary vessels and is in direct relation with development of diabetic retinopathy. Hence, discovery of novel molecules capable of modulating angiogenic events are of great clinical importance. Recent studies have demonstrated multiple angio-regulatory activities for endocannabinoid system modulators and endocannabinoid-like molecules, as well as their metabolizing enzymes. Hence, in present article, we reviewed the regulatory roles of these molecules on angiogenesis and described molecular mechanisms underlying them.

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Development of a recombinant anti-VEGFR2-EPCAM bispecific antibody to improve antiangiogenic efficiency

Cited by 9 publications

References 53 publications

Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

Endocannabinoids and related compounds as modulators of angiogenesis: Concepts and clinical significance

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