Development of a seeding device and procedure and first implantation of an autologously endothelialized homograft

Cardiac Valves: Biologic and Synthetic

“…7 The primary cell types found in the aortic valve are valvular endothelial cells (VEC) and valvular interstitial cells (VIC). These include human saphenous vein endothelial cells, 10,11 ovine circulating endothelial progenitor cells, 12 and ovine carotid artery endothelial cells, 13 which have all been assessed for their potential in fulfilling the role of VICs. They function primarily in maintaining a nonthrombogenic surface, while it is thought that they play a role in regulating the activity of the VICs, 8 which are present in the underlying spongiosa layer.…”