Development of a sensitive flow‐injection–chemiluminescence detection method for the determination of laevodopa

Abstract

A simple chemiluminometric method using flow injection has been developed for the determination of levodopa, based on its sensitizing effect on the weak chemiluminescence (CL) reaction between Na(2)SO(3) and acidic KMnO4. Under optimum experimental conditions, the CL intensity was linearly related to the concentration of levodopa from 3.4 x 10(-8) to 2.4 x 10(-5) mol/L and the detection limit was 1.1 x 10(-8) mol/L (s:n = 3). The relative standard deviation (RSD) of the proposed method calculated from 20 replicate injection of 3 x 10(-7) mol/L levodopa was 3.3%. The correlation coefficient was 0.997. The method was successfully applied to the determination of levodopa in commercial pharmaceutical formulations and spiked urine samples.

Green and efficient determination of ʟ-dopa in complex polypill formulations using a magnetic microplate

“…A number of methods for the analysis of ʟ-dopa in pharmaceutical formulations have been reported to date, including spectrophotometry (3,4), multivariate calibration of kinetic-spectrophotometric methods (5,6), H-point standard addition methods (7), chemiluminescence (8), fluorometry (9), voltammetry (10), high-performance liquid chromatography (11)(12)(13), capillary electrophoresis (14), and liquid chromatography tandem-mass spectrometry (15). Of the various methods reported, spectrophotometry is perhaps the most convenient analytical technique for routine analysis because of its inherent simplicity, low cost, and wide availability in quality-control laboratories.…”

Size–Dependent Active Effect of Cadmium Telluride Quantum Dots on Luminol–Potassium Periodate Chemiluminescence System for Levodopa Detection

“…Various analytical methods have been proposed for the determination of levodopa, such as spectrophotometry, 4 spectrofluorimetry, 5,6 1 H nuclear magnetic resonance spectroscopy, 7 electrochemistry, 8,–10 chemiluminescence (CL), 11 capillary electrophoresis, 12,–14 and high-performance liquid chromatography. 15,–17 The expensive instrumentation, time consumption, and low sensitivity were some of the reported shortcomings of these methods.…”

Flow‐injection chemiluminescence determination of acetylsalicylic acid based on its enhancing effect on the lucigenin–hydrogen peroxide system

“…Chemiluminescence (CL) is usually generated by fast reactions which give rise to imprecise measurements as a result of irreproducible mixing of sample and reagents, but when coupled with flow‐injection analysis (FIA), the CL‐based FIA methods provide cheap, rapid, simple and reproducible means of detection . In recent years, the CL method has been popular for the analysis of pharmaceutical compounds because of its promising advantages of low detection limit, wide linear dynamic range and relatively simple and inexpensive instrumentation .…”