“…Compared to other large ocean basins, the Mediterranean Sea can be considered ideal to improve our understanding of the processes that influence and drive oxygen isotope variations, and to further develop the existing modelling approach, because (i) the water residence time is relatively short (∼ 100 years; Millot and Taupier-Letage (2005)); (ii) all major forcing mechanisms are present, including air-sea interaction, buoyancy fluxes and wind forcing, with a well-studied salinity and water isotope structure (e.g., Pierre, 1999); (iii) a well marked δ 18 O sw of the surface waters of the eastern Mediterranean basin (value up to 2.2 ‰, Gat et al, 1996) has the potential as an oceanographic tracer to trace the process of deep water formation and the thermohaline circulation variability; (iv) a high spatial resolution regional model (NEMO-MED12) is available, which is essential for the simulation of realistic ocean dynamics, and which can then be used for past climate simulation with the adapted coupled regional model (Vadsaria et al, 2020). Over the last decades, considerable progress has been achieved in our understanding of the processes and mechanisms governing the distribution of water isotopes in the Mediterranean Sea, through high quality sampling and measurements (e.g., Gat et al, 1996;Pierre, 1999;LeGrande and Schmidt, 2006).…”