Development of a Set of Nomograms to Predict Acute Lower Gastrointestinal Toxicity for Prostate Cancer 3D-CRT

Valdagni, Riccardo; Rancati, T.; Fiorino, Claudio; Fellin, Gianni; Magli, A.; Baccolini, Michela; Bianchí, C.; Cagna, E.; Greco, Carlo; Mauro, F.; Monti, A.F.; Muñoz, Fernándo; Stasi, M.; Franzone, P.; Vavassori, V.

doi:10.1016/j.ijrobp.2007.11.037

Cited by 69 publications

(47 citation statements)

References 35 publications

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“…25 Maybe the introduction of MRI in the target definition phase will contribute to perform a better delineation of CTV and OARs. 26,27 Analyzing our toxicity data in correlation with patients' clinical variables, the log-rank test evidenced a protective effect of hormonal therapy on the intestinal tissue (weak correlation), as reported in other studies 28,29 and demonstrated in animal models. 30 We found that antihypertensive medication increases the risk of acute GI toxicity, whereas it seems to have a protective effect in the series by Fellin et al 31 Finally, the use of anticoagulants or antiaggregants is weakly associated to late GI toxicity, as reported by Choe et al 29 and Takeda et al 32 Our Cox proportional hazards regression confirms the relation between dose-volume parameters (maximal dose to the rectum, and bladder V 65 ) and toxicity.…”

Section: Resultssupporting

confidence: 75%

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

Ingrosso

Carosi

Cristino

et al. 2017

Reports of Practical Oncology & Radiotherapy

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Section: Resultssupporting

confidence: 75%

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

Ingrosso

Carosi

Cristino

et al. 2017

Reports of Practical Oncology & Radiotherapy

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“…Mean rectal dose is a strong predictor of acute rectal toxicity due to radiotherapy for prostate cancer (33). Patients who have acute rectal toxicity are more likely to have late rectal toxicity (23,34).…”

Section: Discussionmentioning

confidence: 99%

Cross-Linked Hyaluronan Gel Reduces the Acute Rectal Toxicity of Radiotherapy for Prostate Cancer

Wilder

Barme

Gilbert

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…Surgical technique (minimally invasive radical prostatectomy vs open radical prostatectomy) and the use of androgen deprivation therapy concurrently with radiation were included as covariates because of their potential effects on long-term morbidity and disease control. 22 Baseline diabetes mellitus and conditions associated with the use of therapeutic anticoagulation (eg, atrial fibrillation and valvular disease) can increase morbidity risk from radiotherapy [23][24][25] and were also included.…”

Section: Control Variablesmentioning

confidence: 99%

Comparative Effectiveness of Intensity-Modulated Radiotherapy and Conventional Conformal Radiotherapy in the Treatment of Prostate Cancer After Radical Prostatectomy

Goldin¹,

Sheets²,

Meyer³

et al. 2013

JAMA Intern Med

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Importance: Comparative effectiveness research of prostate cancer therapies is needed because of the development and rapid clinical adoption of newer and costlier treatments without proven clinical benefit. Radiotherapy is indicated after prostatectomy in select patients who have adverse pathologic features and in those with recurrent disease.Objectives: To examine the patterns of use of intensitymodulated radiotherapy (IMRT), a newer, more expensive technology that may reduce radiation dose to adjacent organs compared with the older conformal radiotherapy (CRT) in the postprostatectomy setting, and to compare disease control and morbidity outcomes of these treatments.Design and Setting: Data from the Surveillance, Epidemiology, and End Results-Medicare-linked database were used to identify patients with a diagnosis of prostate cancer who had received radiotherapy within 3 years after prostatectomy.Participants: Patients who received IMRT or CRT. Main Outcomes and Measures:The outcomes of 457 IMRT and 557 CRT patients who received radiotherapy between 2002 and 2007 were compared using their claims through 2009. We used propensity score methods to balance baseline characteristics and estimate adjusted incidence rate ratios (RRs) and their 95% CIs for measured outcomes.Results: Use of IMRT increased from zero in 2000 to 82.1% in 2009. Men who received IMRT vs CRT showed no significant difference in rates of long-term gastrointestinal morbidity (RR, 0.95; 95% CI, 0.66-1.37), urinary nonincontinent morbidity (0.93; 0.66-1.33), urinary incontinence (0.98; 0.71-1.35), or erectile dysfunction (0.85; 0.61-1.19). There was no significant difference in subsequent treatment for recurrent disease (RR,1.31; 95% CI, 0.90-1.92).Conclusions and Relevance: Postprostatectomy IMRT and CRT achieved similar morbidity and cancer control outcomes. The potential clinical benefit of IMRT in this setting is unclear. Given that IMRT is more expensive, its use for postprostatectomy radiotherapy may not be cost-effective compared with CRT, although formal analysis is needed.

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Development of a Set of Nomograms to Predict Acute Lower Gastrointestinal Toxicity for Prostate Cancer 3D-CRT

Cited by 69 publications

References 35 publications

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

Volumetric image-guided highly conformal radiotherapy of the prostate bed: Toxicity analysis

Cross-Linked Hyaluronan Gel Reduces the Acute Rectal Toxicity of Radiotherapy for Prostate Cancer

Comparative Effectiveness of Intensity-Modulated Radiotherapy and Conventional Conformal Radiotherapy in the Treatment of Prostate Cancer After Radical Prostatectomy

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