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Introduction. Preventive measures, including the development of a system for diagnosing early signs of changes in the health status of employees and predicting individual risks of developing the disease, aimed at preserving labor resources, reducing disability and extending working life expectancy, are an absolute priority in the field of occupational safety. The aim of the study to develop a prognostic model of the risk of developing asbestosis based on molecular genetic studies in employees of enterprises for the extraction and enrichment of chrysotile asbestos. Materials and methods. Based on studies previously conducted in the Laboratory of Biomedical Research at the Izmerov Research Institute of Occupational Health, scientists have identified a set of informative and significant single-nucleotide polymorphic gene variants for use as predictors in the construction of a prognostic model in the development of asbestos in workers of enterprises for the extraction and enrichment of chrysotile asbestos. We examined 136 people who worked at the enterprise for the extraction and enrichment of chrysotile asbestos. The researchers formed two groups comparable in terms of work experience, dustiness, age and gender: 68 former employees of the main production specialties with an established diagnosis of asbestos and 68 workers without bronchopulmonary pathology. The authors calculated the exposure dose of chrysotile-containing dust and calculated it taking into account the percentage of time spent at the workplace, and also performed a molecular genetic study of single-nucleotide polymorphic variants of the genes IL-1β rs16944, IL-4 rs2243250, TGF-β1 rs1800471, SOD-2 rs4880 and MMP-9 rs17576. Results. A predictive model has been developed to determine the probability of developing asbestosis in workers of an enterprise for the extraction and enrichment of chrysotile asbestos based on the determination of single nucleotide polymorphisms IL-1β rs16944, SOD-2 rs4880 and MMP-9 rs17576. The results of genetic tests are entered into the formula and if the resulting probability of developing asbestosis is equal to or higher than the threshold (0.582), the employee is included in the high-risk group. The sensitivity and specificity of the developed model were 70.1% and 70.6%, respectively. Conclusion. Molecular genetic indicators can act as predictors in the development of asbestosis in workers of the chrysotile extraction and enrichment industry and can be used to form high-risk groups during preventive measures. Ethics. The study was conducted in compliance with ethical standards that guarantee respect for all research subjects and the protection of their health and rights in accordance with the requirements of the Helsinki Declaration of the World Medical Association. All persons included in the study gave informed voluntary consent to the examination in accordance with Federal Law No. 323-FZ dated 11/21/2011 "On the Basics of Public Health Protection in the Russian Federation". The study was approved by the conclusion of the local Ethics committee of Izmerov Research Institute of Occupational Health (minutes of the meeting of the Ethics committee of Izmerov Research Institute of Occupational Health No. 9 dated 11/29/2016).
Introduction. Preventive measures, including the development of a system for diagnosing early signs of changes in the health status of employees and predicting individual risks of developing the disease, aimed at preserving labor resources, reducing disability and extending working life expectancy, are an absolute priority in the field of occupational safety. The aim of the study to develop a prognostic model of the risk of developing asbestosis based on molecular genetic studies in employees of enterprises for the extraction and enrichment of chrysotile asbestos. Materials and methods. Based on studies previously conducted in the Laboratory of Biomedical Research at the Izmerov Research Institute of Occupational Health, scientists have identified a set of informative and significant single-nucleotide polymorphic gene variants for use as predictors in the construction of a prognostic model in the development of asbestos in workers of enterprises for the extraction and enrichment of chrysotile asbestos. We examined 136 people who worked at the enterprise for the extraction and enrichment of chrysotile asbestos. The researchers formed two groups comparable in terms of work experience, dustiness, age and gender: 68 former employees of the main production specialties with an established diagnosis of asbestos and 68 workers without bronchopulmonary pathology. The authors calculated the exposure dose of chrysotile-containing dust and calculated it taking into account the percentage of time spent at the workplace, and also performed a molecular genetic study of single-nucleotide polymorphic variants of the genes IL-1β rs16944, IL-4 rs2243250, TGF-β1 rs1800471, SOD-2 rs4880 and MMP-9 rs17576. Results. A predictive model has been developed to determine the probability of developing asbestosis in workers of an enterprise for the extraction and enrichment of chrysotile asbestos based on the determination of single nucleotide polymorphisms IL-1β rs16944, SOD-2 rs4880 and MMP-9 rs17576. The results of genetic tests are entered into the formula and if the resulting probability of developing asbestosis is equal to or higher than the threshold (0.582), the employee is included in the high-risk group. The sensitivity and specificity of the developed model were 70.1% and 70.6%, respectively. Conclusion. Molecular genetic indicators can act as predictors in the development of asbestosis in workers of the chrysotile extraction and enrichment industry and can be used to form high-risk groups during preventive measures. Ethics. The study was conducted in compliance with ethical standards that guarantee respect for all research subjects and the protection of their health and rights in accordance with the requirements of the Helsinki Declaration of the World Medical Association. All persons included in the study gave informed voluntary consent to the examination in accordance with Federal Law No. 323-FZ dated 11/21/2011 "On the Basics of Public Health Protection in the Russian Federation". The study was approved by the conclusion of the local Ethics committee of Izmerov Research Institute of Occupational Health (minutes of the meeting of the Ethics committee of Izmerov Research Institute of Occupational Health No. 9 dated 11/29/2016).
Introduction. An increase in life expectancy, a decrease in the mortality rate of the working-age population and an extension of working longevity are the most important components in the development of the human potential of the Russian Federation. We observe the most unfavorable situation with the achievement of the above-mentioned targets in coal mining. The study aims to substantiate the priority directions for preserving the health of workers engaged in underground coal mining in modern production conditions based on an assessment of occupational risks to prolong their working longevity. Materials and methods. The authors have carried out the analysis of official statistics data (state reports of Rospotrebnadzor and the annual report of Rosstat) for 2021–2022 on the state of working conditions and occupational morbidity in the coal industry. We have summarized the materials of Rosugleprof for 2006–2022 on occupational morbidity in coal industry organizations. We have presented the data of epidemiological studies in a cohort of coal miners on the example of the Rostov region. Results. The authors note the largest proportion of cases of occupational pathology among employees of mining enterprises — 40.3%. The most at risk are: sinkers (10.2% of all newly identified cases of occupational diseases in 2022), miners of the treatment face (6.5%), excavator drivers (4.5%). In the structure of occupational morbidity of miners, the leading place is occupied by radiculopathy — 27.0%; sensorineural hearing loss — 22.9%; vibration disease — 22.0%; respiratory diseases (occupational bronchitis, pneumoconiosis, COPD) — more than 15.5%. In a cohort of miners with an established diagnosis of occupational diseases, it was shown that the standardized relative risk (SRR) of death from diseases of the circulatory system was 1.55 times significantly higher compared with the control population. Mortality from malignant neoplasms in miners was 44% higher than mortality in the population (SRR=1.44). At the same time, the death rate from the subclass malignant neoplasms of the respiratory system was 2.02 (95% CI 1.85–2.20), and from malignant neoplasms of the bronchi and lungs 2.24 (95% CI 2.04–2.46). The risk of death from respiratory diseases in the cohort of miners was more than 2 times higher than the population indicator (SRR=2.18). A significantly higher frequency of deaths from this class of diseases indicates a causal relationship with dust loads. The prevalence of coronary heart disease (CHD) among coal mine workers is higher than among the unorganized population of large cities and other groups of industrial workers. Conclusion. Scientists have recorded the most unfavorable working conditions in underground coal mining, which is due to the technologies used and production conditions. The prevention of diseases among miners requires the creation of health groups and the improvement of medical examination methods. Development of an integrated information system for health monitoring and personalized preventive and rehabilitation measures. To solve this problem, it is necessary to study working conditions, scientifically substantiate preventive measures, harmonize special assessment of working conditions and develop criteria for severity and intensity of work, as well as improve the technology for assessing working conditions and personalized risk assessment. Ethics. The study did not require the conclusion of the Ethics committee.
In order to increase the healthy life expectancy and reduce the total temporary disability of the working population, special attention should be paid to the prevention of diseases. The modern level of scientific and technical progress allows to increase the efficiency of solving the problems of preventive medicine through the application of digital technologies. Digital preventive medicine must become an independent research field. The article characterizes the status and prospects of digitalization of key areas of preventive medicine with an emphasis on technologies to preserve the health of the working population. The current issues of digitalization of preventive medicine and priorities of its further development are identified.
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