Development of a simple, eco-friendly HPLC-DAD method for tulathromycin analysis: Ensuring stability and assessing greenness

Algethami, Faisal K.; Gamal, Mohammed

doi:10.1016/j.microc.2023.109511

Cited by 15 publications

(1 citation statement)

References 52 publications

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“…Performing 50 or more samples per week is considered the most environmentally friendly approach. In our example the number of samples analyzed in seven days is approximately 500, which means a high green value in terms of economic cost according to the HEXAGON tool description 35 , 36 .…”

Section: Resultsmentioning

confidence: 99%

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

Demir,

Bulduk,

Darwısh

et al. 2024

Sci Rep

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Green spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a combination of ethanol and formic acid solution (pH 2.0; 30:70 v/v). Isocratic elution was applied and the flow rate was set at 1.0 mL min−1. Metoclopramide was detected at 273 nm. The methods performed were economical, rapid, environmentally friendly, and simple, providing metoclopramide analysis within 5 min. The methods have been successfully applied in pharmaceutical products without matrix interference. The results of the application of the developed methods to pharmaceutical products were statistically compared and no significant difference was observed between the methods. In addition, the greenness assessment of the developed methods was performed using AGREE software. Our developed methods, based on the use of solvents such as ethanol and water, are proposed as a more environmentally and analyst-friendly option for the quantification of metoclopramide in pharmaceutical products than other methods currently in use.

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Section: Resultsmentioning

confidence: 99%

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

Demir,

Bulduk,

Darwısh

et al. 2024

Sci Rep

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Novel Stability–Indicating Reverse‐Phase High‐Performance Liquid Chromatography Technique for Apremilast Quantification in Pharmaceuticals and Nanovesicular Systems: A Design of Experiment Approach

Sutar,

Jalalpure,

Kurangi

2024

Separation Science Plus

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An accurate and precise reverse‐phase high‐performance liquid chromatographic technique for apremilast (APR) quantification in bulk, commercial tablets, and formulated APR‐loaded nanoformulations was developed and validated by the design of the experiment approach in accordance with the International Conference of Harmonization guidelines. APR was separated by using formic acid buffer (0.1%; pH 3.2):methanol (40:60, v/v) as a solvent system with a flow rate of 1 mL/min and was detected at a wavelength of 230 nm with a retention time of 7.1 min. The central composite design was employed to optimize the developed analytical method. The calibration curve for APR was linear (r2 = 0.999), with a limit of detection of 0.5 µg/mL and a limit of quantification of 1.52 µg/mL, respectively. A recovery of APR in tablet and nanoformulation was observed in the 98.56%–99.32% range. Forced degradation studies revealed the stability of the proposed analytical method, as the APR peak remained unchanged under stress‐induced degradation experiments. Hence, the proposed chromatographic technique with a cost‐effective solvent system could be employed in the pharmaceutical industry for estimating APR in various formulations.

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Enhancing the practicality along with greenness sustainability of a high throughput HPLC-MS/MS bioanalytical method for the simultaneous determination of amlodipine, perindopril, and its active metabolite perindoprilat in human plasma: Application to a pharmacokinetic study

Elkady,

Moffid,

Mostafa

et al. 2025

Journal of Chromatography A

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Development of a simple, eco-friendly HPLC-DAD method for tulathromycin analysis: Ensuring stability and assessing greenness

Cited by 15 publications

References 52 publications

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

Novel Stability–Indicating Reverse‐Phase High‐Performance Liquid Chromatography Technique for Apremilast Quantification in Pharmaceuticals and Nanovesicular Systems: A Design of Experiment Approach

Enhancing the practicality along with greenness sustainability of a high throughput HPLC-MS/MS bioanalytical method for the simultaneous determination of amlodipine, perindopril, and its active metabolite perindoprilat in human plasma: Application to a pharmacokinetic study

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