Development of a Simple In-Die Method for Determination of Capping Tendency in Rotary Tableting Machines

Abstract

A rotary tableting machine is used for the continuous tableting process. Tableting conditions often result in capping, leading to serious problems during production. Several studies have been conducted to predict the tablet capping tendency. However, as most previous studies were conducted using a compaction simulator, there is a lack of technology that can be readily applied during actual production. Therefore, the present study aimed to develop a novel method for predicting tablet capping in a rotary tableting machine. We hypothesized that capping occurs when residual stress of the tablet inside a die exceeds the critical stress immediately before ejection.Residual stress was evaluated by measuring the in-line die-wall pressure in a rotary tableting machine. Additionally, critical stress was estimated from the tablet strength inside the die using the Rumpf's equation. The critical and residual stresses were compared to determine the capping tendency to some extent. The findings of this study will substantially contribute to the rapid detection of tablet capping during tablet production.

Quality assessment of metformin hydrochloride tablets retailed in Lagos, Nigeria

“…However, the variation in the weight of the tablets may be explained by the following factors such as the flowing properties of the powder, the speed of the tableting machine, the pressure used in compression, and the type of machines used in tableting (Peeters et. al., 2015: Imayoshi et. al., 2023Spaniol et.…”