Development of a Soft Contact-Lens Biosensor for In-vivo Tear Glucose Monitoring

Chu, M. K.; Iguchi, Shigehito; Miyajima, Koichiro; Arakawa, Takahiro; Kudo, Hiroyuki

doi:10.1007/978-3-642-23508-5_262

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…These results provide not only an alternative solution for manufacturing advanced smart contact lenses but also a novel insight into designing other multifunctional implantable bioelectronics. In addition, our integrated contact lens sensor system and fabrication strategy allows for incorporation of other functional components, such as electrode arrays for electroretinograms, 36 , 37 antennas for wireless communication 25 , 26 , 27 and power modules (e.g., thin-film batteries/supercapacitors), 100 , 101 , 102 biofuel cells, 103 moisture-based energy harvesting, 104 or wireless radiofrequency 105 for future in vivo research.…”

Section: Resultsmentioning

confidence: 99%

“… 24 Smart contact lenses equipped with high sensitivity glucose sensors could open the possibility of a non-invasive method to continuously detect biomarkers in tears. 25 , 26 , 27 , 28 , 29 Owing to the abundant proteins or biomarkers from tear fluid, smart contact lenses are expected to provide higher accuracy/reliability of the resulting data in comparison with the analyses from skin or sweat by other conventional wrist-worn watches or smart patches. Although controversy may remain, recent studies have shown that the blood glucose concentrations estimated with the tear glucose concentrations obtained by glucose sensors exhibit a high correlation with those actually measured with a clinically available glucometer (R 2 = 0.9617).…”

Section: Introductionmentioning

confidence: 99%

“…36 Monitoring ocular temperature after ophthalmic surgery also has clinical significance in case of postoperative infection. 35 The smart contact lenses could also be equipped with application-specific integrated circuit chips, 26 multiple electrode arrays, 37 , 38 or antenna 25 , 39 to further enrich their functionality to obtain, process, and transmit physiological properties, manage illnesses and health risks, and finally promote health and wellbeing.…”

Section: Introductionmentioning

confidence: 99%

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Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors

Guo

et al. 2021

Matter

125

123

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Smart contact lenses attract extensive interests due to their capability of directly monitoring physiological and ambient information. However, previous demonstrations usually lacked efficient sensor modalities, facile fabrication process, mechanical stability, or biocompatibility. Here, we demonstrate a flexible approach for fabrication of multifunctional smart contact lenses with an ultrathin MoS 2 transistors-based serpentine mesh sensor system. The integrated sensor systems contain a photodetector for receiving optical information, a glucose sensor for monitoring glucose level directly from tear fluid, and a temperature sensor for diagnosing potential corneal disease. Unlike traditional sensors and circuit chips sandwiched in the lens substrate, this serpentine mesh sensor system can be directly mounted onto the lenses and maintain direct contact with tears, delivering high detection sensitivity, while being mechanically robust and not interfering with either blinking or vision. Furthermore, the in vitro cytotoxicity tests reveal good biocompatibility, thus holding promise as next-generation soft electronics for healthcare and medical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors

Guo

et al. 2021

Matter

125

123

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Wearable Technologies for Glucose Monitoring

Iyawa

Velusamy

Palanisamy

2019

The IoT and the Next Revolutions Automating the World

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With the increasing prevalence of diabetes mellitus, it has become of utmost importance for wearable technologies for glucose monitoring to be introduced in different contexts. While there is a high number of research on noninvasive techniques for glucose monitoring of diabetes mellitus, there is a shortage of studies discussing the publication trend of wearable technologies that support glucose monitoring. The primary purpose of this chapter was to conduct a Systematic Mapping Study of publication trends relating to wearable technologies for glucose monitoring. This study adopted a Systematic Mapping Study approach in identifying relevant papers for analysis. Articles were identified from relevant databases including IEEE Xplore, ACM Digital Library, ScienceDirect and Scopus. A total of 29 papers met the inclusion criteria. The findings of this study are expected to inform health informatics experts and academics on the current research and publication trends in wearable technologies for glucose monitoring.

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Development of a Soft Contact-Lens Biosensor for In-vivo Tear Glucose Monitoring

Cited by 2 publications

References 6 publications

Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors

Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors

Wearable Technologies for Glucose Monitoring

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