2019
DOI: 10.1002/ejlt.201800258
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Development of a Solid Self‐Emulsification Delivery System for the Oral Delivery of Astaxanthin

Abstract: In the present study, a solid self‐emulsification delivery system (S‐SEDS) is developed to improve the bioavailability of astaxanthin (ASX). The pseudo ternary phase diagram method is used to screen the optimum composition of liquid self‐emulsification delivery system (SEDS). This liquid system is converted into solid state using the solid absorbent carrier by simple physical mixing. Through the analysis of powder flowability and adsorption capacity, silicon dioxide and anhydrous calcium hydrogen phosphate are… Show more

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Cited by 15 publications
(9 citation statements)
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“…To investigate whether astaxanthin was successfully loaded in PLGA nanoparticles, the FTIR experiment was carried out. As shown in figure 3, the astaxanthin presented characteristic absorption peaks at 2922 cm −1 , 1650 cm −1 , 1551 cm −1 and 976 cm −1 , which are attributed to −CH 3 stretching, the C=O stretching vibration, the stretching vibration of C=C in the aromatic ring and C–H in the C and C conjugate system, respectively [36,37]. All bands of blank PLGA NP could be found in the spectra of AST-PLGA NP.…”
Section: Resultsmentioning
confidence: 99%
“…To investigate whether astaxanthin was successfully loaded in PLGA nanoparticles, the FTIR experiment was carried out. As shown in figure 3, the astaxanthin presented characteristic absorption peaks at 2922 cm −1 , 1650 cm −1 , 1551 cm −1 and 976 cm −1 , which are attributed to −CH 3 stretching, the C=O stretching vibration, the stretching vibration of C=C in the aromatic ring and C–H in the C and C conjugate system, respectively [36,37]. All bands of blank PLGA NP could be found in the spectra of AST-PLGA NP.…”
Section: Resultsmentioning
confidence: 99%
“…To determine its content, the astaxanthin in NLCs was extracted with a mixture of 4:1 v/v dichloromethane:ethanol. [ 26 ] Then, the extracted solution was filtered through a 0.45 μm nylon syringe filter, followed by UV spectrophotometric analysis (755B, JINGHUA, Shanghai, China) at 478 nm. [ 26 ]…”
Section: Methodsmentioning
confidence: 99%
“…In a stream of hot air, the technique effectively converts the liquid phase into a dry granular phase. Considering that the properties of solids (e.g., low costs of production, easy process control, well stability and reproducibility, and good patient compliance) and selfemulsifiers (e.g., increased solubility and bioavailability), solid self-emulsifying delivery systems can enhance the bioavailability of a drug through the formation of a large specific surface area [44]. Moreover, a solidification technique with adsorption onto a solid carrier was used to prepare new formulation.…”
Section: Sift Deskmentioning
confidence: 99%
“…Moreover, a solidification technique with adsorption onto a solid carrier was used to prepare new formulation. In vitro studies on the physicochemical properties of astaxanthin S-SEDS are important for the application of astaxanthin in functional foods [44].…”
Section: Sift Deskmentioning
confidence: 99%