Development of a Stability Indicating Method and Study of Forced Degradation Pathway of Choline Theophyllinate and Salbutamol by Liquid Chromatography–Mass Spectrometry

Gaddey, Pridhvi Krishna; Sundararajan, Raja

doi:10.1007/s42250-023-00780-7

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…Among the available methods for TPL determination such as an electro membrane extraction combined with high-performance liquid chromatography-ultraviolet [5], liquid chromatography-mass spectrometry [6], liquid chromatography-tandem mass spectrometry [7], chemical sensor [8], electrochemical approaches have the potential to detect drugs in body fluids and pharmaceutical formulations due to their high selectivity and sensitivity, in situ measurement, simple sample preparation procedures, low cost and simple operation compared with other approaches [9,10]. Various electrochemical sensors modified with hybrid nanocomposite materials have been employed for the electrochemical sensing of electroactive compounds of interest, such as metal ions [11] and pharmaceutical compounds, owing to their novel functional properties [12,13].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical determination of theophylline using a nickel ferrite/activated carbon-modified electrode

Thanh,

Nam,

Dung

et al. 2024

Mater. Res. Express

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In this work, a nanocomposite based on nickel ferrite/activated carbon (NiF/AC) was used to modify a highly sensitive electrochemical sensor for the quantification of theophylline (TPL) in pharmaceutical tablets. The synthesized materials were characterized using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy-elemental mapping and surface area analysis via the Brunauer‒Emmett‒Teller method. Cyclic voltammetry was employed to study the electrocatalytic properties of the NiF/AC-GCE toward the oxidation of TPL. The dependence of the electrochemical response on the scan rate and pH was also investigated, and the working parameters were optimized. The linear range of the established electrochemical biosensor was from 0.5 to 5 μM (R2 = 0.997), with a detection limit of 0.21 μM. The present method was tested using three pharmaceutical formulation standard samples with good accuracy and acceptable recovery. Thus, it is a promising candidate for the determination of TPL in pharmaceutical formulations.

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