Development of a system for simultaneous dissolution studies and magnetic resonance imaging of water transport in hydrodynamically balanced systems: A technical note

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

“…The advantages of MRI include high soft tissue contrast, high temporal and spatial resolution, as well as a lack of ionizing irradiation. Also, harmless paramagnetic and supra-magnetic MR imaging contrast agents can be applied to specifically enhance or suppress signal of fluids and tissues of interest and thus permit better delineation and study of organs (Dorozynski et al, 2007).…”

Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging

“…Further, when MRI is combined with a flowthrough cell apparatus for use in compendial analysis (European Pharmacopoeia, sixth ed., 2007; The Japanese Pharmacopoeia 15th ed., 2006;The United States Pharmacopeia 31-National Formulary 26, 2007) (Fig. 1), the physical changes in solid dosage forms can be examined in a dissolution test (Dorożyński et al, 2007;Fyfe et al, 2000;Kulinowski et al, 2008;Nott, 2010). Indeed, Fyfe et al (2000) used such a combined system to assess drug delivery devices and thereby obtain a better understanding of drug delivery systems based on diffusion, dissolution, and osmosis mechanisms.…”

“…Indeed, Fyfe et al (2000) used such a combined system to assess drug delivery devices and thereby obtain a better understanding of drug delivery systems based on diffusion, dissolution, and osmosis mechanisms. Further, Dorożyński et al (2007) and Kulinowski et al (2008) carried out the compendial flow-through cell dissolution method for a HPMC matrix using two different solutions; fasted state simulating gastric fluid (FaSSGF) and fed state simulating gastric fluid (FeSSGF), under the continuous flow conditions to simulate in vivo conditions as closely as possible. However, the integrated investigation of the drug release mechanism from PEO hydrogel matrix tablet among the cumulative drug release profiles, the contribution of hydrogel matrix erosion and the conformation changes of the hydrogel under the compendial flow-through cell dissolution method have not been reported.…”

Imaging hydrogel implants in situ

“…36,37,38 Further, as T 2 derives from molecular motion/water mobility, this parameter can be used in the characterization of implanted hydrogels. For example, in chondral defects treated with a photopolymerizable hydrogel, a decrease in T 2 was shown to correlate with an increase in repair tissue (presumably replacing the hydrogel).…”