Development of a taste-masked oral suspension of clindamycin HCl using ion exchange resin Amberlite IRP 69 for use in pediatrics

Alayoubi, Alaadin; Daihom, Baher; Adhikari, H.; Mishra, Sanjay R.; Helms, Richard A.; Almoazen, Hassan

doi:10.3109/03639045.2016.1160102

Cited by 28 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The palatability of BZL liquid formulation was also determined in a randomised study by six healthy human volunteers in an intake and spit test . The bitterness level of placebo cherry flavour solution (sample A) was recorded against the BZL final formulation (sample B) and the optimised BZL co‐solvent solution (sample C) using a numerical scale . As seen in Figure , the placebo formulation and the flavoured BZL final solution displayed scores between 0 and 2, which suggested that the final formulation was slightly bitter.…”

Section: Resultsmentioning

confidence: 99%

“…They were asked to record the bitterness score through a numerical scale between 0 and 4, where 0, 1, 2, 3 and 4 were not bitter, slightly bitter, moderately bitter, bitter and very bitter, respectively. A final score of bitterness was calculated by the average of the value measured for each sample . The protocol of this assay was reviewed and approved by the Bioethics Committee of the National University of Rosario (Argentina) according to the Declaration of Helsinki.…”

Section: Taste Masking Analysismentioning

confidence: 99%

See 1 more Smart Citation

Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality‐by‐design approach

Souza

Real

Leonardi

et al. 2017

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Taste Masking Analysismentioning

confidence: 99%

Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality‐by‐design approach

Souza

Real

Leonardi

et al. 2017

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…This can be explained by the good dispersibility of powder in presence of MD, as stated earlier. Another reason could be possible masking of the astringent flavour of Dillenia indica juice by MD, which has often been reported to mask undesirable flavours and odours during spray drying (Abraham & Mathew, 2013;Alayoubi et al, 2016;Bertelsen, Laursen, Knudsen, Møller, & Kidmose, 2018).…”

Section: B = MDmentioning

confidence: 99%

Whey Fortified Ready-to-Reconstitute Elephant Apple (Dillenia Indica) Juice Powder: Methodical Optimization, Micro-Structural and in Vitro Digestion Analyses

Borah

Boruah

Islam

et al. 2022

jftr

View full text Add to dashboard Cite

Elephant apple fruit, though bestowed with multifarious medicinal properties and available in many Asian countries, has no known commercial processed product due to its tough fibrous calyces, highly astringent juice and brown discolouration. In this study, the juice was blended with concentrated whey in different proportions (v/v) for assessing organoleptic acceptability. Principal Component Analysis of the sensory scores and subsequent evaluation of blends’ antioxidant activity revealed the superiority of 1:1 (v/v) admixture over other counterparts. Further, study focussed on optimization of process variables (maltodextrin concentration and inlet temperature of spray dryer) for recuperating beverage powder from the juice-whey blend (1:1 v/v). Developed powders presented different surface morphologies (wrinkled/shrunk/ellipsoidal/fused particles having 2-30 µm diameters), and were organoleptically favourable with good yield (63.33-88.33%), dispersibility (33.40-56.57%), moderate antioxidative potential (37.45-54.57%), improved sugar, protein and whiteness index. In-vitro digestion release of protein and antioxidant activity from the optimized powder showed increasing trend with time, unlike those of fresh juice and juice-whey blend (1:1 v/v). Thus, ready-to-reconstitute juice powder(s) with appreciable features was developed from an underutilized fruit using methodical statistical approaches, and the resultant product was found to provide protracted release of protein and antioxidants during simulated digestion.

show abstract

“…Besides the foremost and simplest approach of adding sweeteners and/or flavors, other taste-masking techniques have also been developed, such as coating drug particles with polymers, forming inclusion complexes, using ion-exchange resins, producing multiparticulate taste-masking systems with lipids by hot-melting extrusion, and so forth (51)(52)(53)(54)(55)(56)(57). As a whole, modification of microparticles based on particle engineering, especially forming a core-shell or embedded structure, occupies an indispensable status.…”

Section: Taste Maskingmentioning

confidence: 99%

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

et al. 2019

View full text Add to dashboard Cite

Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (including fast-release systems, sustained-release systems, and targeted-release systems). However, there are certain problems in the practical application, such as bitter taste and coating damage. Combining with some polymer or lipid materials to form core-shell or embedded structures is considered as the key to taste masking. And, using cushioning agents is proven to be effective in preserving the integrity of the functional coating film of multiparticulates during tableting. To sum up, this review, from a particle engineering point, expounds the influence of different factors on the functionality of particles and offers some useful comments and suggestions for industry personnel.

show abstract

Development of a taste-masked oral suspension of clindamycin HCl using ion exchange resin Amberlite IRP 69 for use in pediatrics

Abstract: Clindamycin/resin complexation has shown to be an efficient method to mask the taste of clindamycin and was developed into a suspension formulation that can be used in pediatrics.

Cited by 28 publications

References 34 publications

Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality‐by‐design approach

Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality‐by‐design approach

Whey Fortified Ready-to-Reconstitute Elephant Apple (Dillenia Indica) Juice Powder: Methodical Optimization, Micro-Structural and in Vitro Digestion Analyses

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

Contact Info

Product

Resources

About