Accidents rank third among the top 10 leading causes of death in Louisiana, claiming more than 2,000 lives out of a total of almost 33,000 deaths. Drivers’ characteristics (age and gender), the geometry of the roadways, driving on the major roadways, the day of the week, and the wet or dry condition or the road have been associated with crash severity. This study applies unordered multinomial logistic models to investigate causes leading to crash severity in Louisiana. Several models were estimated and the best results were retained for presentation and discussion. Consistent with previous research, findings suggest that drivers’ gender and age matter for traffic safety. Individually, male and older drivers are too risky. Major roads, weekdays, dry surfaces, and road geometry increase the risk of fatal accidents. Male drivers are prone to severe and fatal accidents while old drivers are vulnerable to all types of accidents. Young drivers and female drivers feature among cases of injury and moderate accidents. Evidence suggests that crash severity is not ethnicity specific, contrary to some studies. This study is relevant because it builds a new dataset for safety research, identifies risk factors, and informs the aim of public safety policy to reduce loss of life, injuries, and costs resulting from motor vehicle accidents.