Development of a three-compartment toxicokinetic model for T-2 toxin in shrimp by blindfold particle swarm optimization algorithm

Ye, Lin; Liu, Jiacun; Wang, Yaling; Sun, Lijun; Fang, Zhijia; Deng, Qi; Qiu, Mei; Zhao, Jian

doi:10.1016/j.ecoenv.2020.111698

Cited by 2 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…El análisis cinético de la acumulación de sustancias tóxicas en el organismo animal o humano se ha reflejado en diversas publicaciones que recurren al análisis farmacocinético convencional, basado en la utilización de modelos compartimentales y fisiológicos, para evaluar el comportamiento toxicocinético de diferentes compuestos y que permite, entre otras aplicaciones, la evaluación de riesgos medioambientales en diferentes ecosistemas (39,40). La Figura 1 muestra la aplicación de diferentes tipos de modelos toxicocinéticos, principalmente compartimentales y fisiológicos para la evaluación de riesgos medioambientales producidos por sustancias químicas (41).…”

Section: Modelos Compartimentalesunclassified

“…La toxina Tricoteceno-2 (T-2) es una micotoxina producida por especies de Fusarium que puede suponer un grave riesgo para la salud animal y humana. Un modelo tricompartimental toxicocinético que considera rápida y lenta metabolización ha sido utilizado para caracterizar la disposición de la toxina T2 en gambas tras su administración por vía intramuscular (39).…”

Section: Modelos Compartimentalesunclassified

See 1 more Smart Citation

Introduction to toxicokinetics from the Royal National Academy of Pharmacy: An example of academic collaboration

Ozonas

Hurlé

Lanao

2022

an.ranf

View full text Add to dashboard Cite

This paper addresses the beginning of toxicokinetics in Spain by the group of Prof. Bartolomé Ribas in the 60s of the last century, as well as the interdisciplinary collaboration that occurs between academics of the Royal National Academy of Pharmacy (RANF) and more specifically with the group of Prof. Rafael Cadórniga, who was a pioneer of Biopharmacy and Pharmacokinetics studies in Spain. This scientific collaboration is a magnificent example of interdisciplinary work between academics as well as the strong interrelationship between toxicokinetics and pharmacokinetics. The work also develops the concepts, methods and advances in toxicokinetics, focusing on analytical methods for the determination of very low concentrations of toxic substances in the animal and human organism, multicompartmental models, physiologically based toxicokinetic models (PBTK), toxicokinetic / toxicodynamic models (TX / TD), population models, Bayesian methods in toxicokinetics as well as the future of this discipline also based on the use of methodologies based on artificial intelligence. Currently, toxicokinetics plays a fundamental role in the development of new medicines, as well as in the evaluation of food safety and environmental risks. Keywords: toxicokinetics; pharmacokinetics; ranf; academic collaboration

show abstract

Section: Modelos Compartimentalesunclassified

Introduction to toxicokinetics from the Royal National Academy of Pharmacy: An example of academic collaboration

Ozonas

Hurlé

Lanao

2022

an.ranf

View full text Add to dashboard Cite

show abstract

“…BFOA‐PSO 50 is a hybrid of BFO 51 for determining a solution by elimination and dispersal stage, and PSO for social information trade‐off. Ye et al 52 utilized PSO to estimate parameters of a three‐compartment toxicokinetic model for the absorption, distribution, metabolism, and elimination of tricothecenes‐2 toxin (T‐2) in shrimp.…”

Section: Parameter Estimation Via Psomentioning

confidence: 99%

Metaheuristics for pharmacometrics

Kim

Hooker

Shi

et al. 2021

CPT Pharmacom & Syst Pharma

View full text Add to dashboard Cite

Metaheuristics is a powerful optimization tool that is increasingly used across disciplines to tackle general purpose optimization problems. Nature‐inspired metaheuristic algorithms is a subclass of metaheuristic algorithms and have been shown to be particularly flexible and useful in solving complicated optimization problems in computer science and engineering. A common practice with metaheuristics is to hybridize it with another suitably chosen algorithm for enhanced performance. This paper reviews metaheuristic algorithms and demonstrates some of its utility in tackling pharmacometric problems. Specifically, we provide three applications using one of its most celebrated members, particle swarm optimization (PSO), and show that PSO can effectively estimate parameters in complicated nonlinear mixed‐effects models and to gain insights into statistical identifiability issues in a complex compartment model. In the third application, we demonstrate how to hybridize PSO with sparse grid, which is an often‐used technique to evaluate high dimensional integrals, to search for D‐efficient designs for estimating parameters in nonlinear mixed‐effects models with a count outcome. We also show the proposed hybrid algorithm outperforms its competitors when sparse grid is replaced by its competitor, adaptive gaussian quadrature to approximate the integral, or when PSO is replaced by three notable nature‐inspired metaheuristic algorithms.

show abstract

Development of a three-compartment toxicokinetic model for T-2 toxin in shrimp by blindfold particle swarm optimization algorithm

Cited by 2 publications

References 23 publications

Introduction to toxicokinetics from the Royal National Academy of Pharmacy: An example of academic collaboration

Introduction to toxicokinetics from the Royal National Academy of Pharmacy: An example of academic collaboration

Metaheuristics for pharmacometrics

Contact Info

Product

Resources

About