Development of a transportable FT-ICR MS associated with a glow discharge ionization source

Vot, Clotilde Le; Bouaziz, M.; Héninger, Michel; Boissel, P.; Mauclaire, G.; Mestdagh, H.; Costa, Filipe; Lemaire, Joël

doi:10.1016/j.ijms.2016.07.005

Cited by 4 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For complex mixture analysis, the number of assigned elemental compositions was doubled. A transportable FT-ICR mass spectrometer was associated with a glow discharge ionization source to detect trace compounds in the air (Le Vot et al, 2016). Polycyclic aromatic hydrocarbons, such as naphthalene, acenaphthene and acenaphthene, were detected.…”

Section: Ft-icr Mass Analyzermentioning

confidence: 99%

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Li¹,

Chu²,

Tan³

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers’ sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers.

show abstract

Section: Ft-icr Mass Analyzermentioning

confidence: 99%

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Li¹,

Chu²,

Tan³

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…They are small (compared to the previous), robust, easy-to-use field instruments for real-time detection of volatile organic compounds in air or water. As the molecules to be detected are in a lower mass range, it is possible to use weaker magnetic fields, of the order of 1 T [ 4 , 5 , 6 , 7 , 8 , 9 ]. This is sufficient to perform mass to charge measurement with an accuracy of Δ m / z 5 × 10 −3 , which allows differentiation of quasi-isobaric species having the same nominal mass but different molecular formulas.…”

Section: Introductionmentioning

confidence: 99%

Compact FTICR Mass Spectrometry for Real Time Monitoring of Volatile Organic Compounds

Lemaire

Thomas

Lopes

et al. 2018

Sensors

View full text Add to dashboard Cite

In this paper, we present a compact Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) designed for real time analysis of volatile organic compounds (VOCs) in air or in water. The spectrometer is based on a structured permanent magnet made with NdFeB segments. Chemical ionization is implemented inside the ICR cell. The most widely used reaction is the proton transfer reaction using H3O+ precursor ions, but other ionic precursors can be used to extend the range of species that can be detected. Complex mixtures are studied by switching automatically from one precursor to another. The accuracy obtained on the mass to charge ratio (Δm/z 5 × 10−3), allows a precise identification of the VOCs present and the limit of detection is 200 ppb without accumulation. The time resolution is a few seconds, mainly limited by the time necessary to come back to background pressure after the gas pulses. The real time measurement will be illustrated by the monitoring of VOCs produced during the thermal degradation of a polymer and by an example where three different precursor ions are used alternatively to monitor a gas sample.

show abstract

“…More recently, two instruments with external ion sources have been presented. , These developments are based on a magnet configuration producing a magnetic field that is coaxial with the magnetic cylinder’s main axis. The strength of the field is 1 T.…”

mentioning

confidence: 99%

Gas Analysis by Electron Ionization Combined with Chemical Ionization in a Compact FTICR Mass Spectrometer

et al. 2018

View full text Add to dashboard Cite

In this Article, a compact Fourier transform ion cyclotron resonance (FTICR) mass spectrometer based on a permanent magnet is presented. This instrument has been developed for real-time analysis of gas emissions. The instrument is well-suited to industrial applications or analysis of toxic and complex samples where the concentrations can vary rapidly on a wide range. The novelty of this instrument is the ability to use either electron ionization (EI) or chemical ionization (CI) individually or both of them alternatively. Also in CI mode, different precursor ions can be used alternatively. Volatile organic compounds (VOCs) from the ppb level to very high concentrations (% level) can be detected by CI or EI. The magnet is composed of three Halbach arrays, and the nominal field achieved is 1.5 T. The ICR cell is a 3 cm side length cubic cell. The mass range is 12-200 u with a broad band detection. The mass accuracy of 0.005 u and the resolving power allow the separation of isobaric ions such as CH and CO. Gas introduction via controlled gas pulses, electron ionization, ion-molecule reactions, ion selection, and detection are all performed in the ICR cell. The potential of the instrument will be illustrated by an analysis of a gas mixture containing trace components at ppm level (VOCs) and components in the 0.5-100% range (N, alkanes, and CO).

show abstract

Development of a transportable FT-ICR MS associated with a glow discharge ionization source

Cited by 4 publications

References 34 publications

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Compact FTICR Mass Spectrometry for Real Time Monitoring of Volatile Organic Compounds

Gas Analysis by Electron Ionization Combined with Chemical Ionization in a Compact FTICR Mass Spectrometer

Contact Info

Product

Resources

About