2016
DOI: 10.3390/molecules22010007
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Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism

Abstract: Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid in rat plasma to investigate the pharmacokinetic profile of different HYD prescript… Show more

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Cited by 19 publications
(10 citation statements)
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“…There are several reports on assaying peimine and peiminine in Bulbus Fritillaria [ 18 , 19 , 23 , 31 ], but no analytical method was developed for the simultaneous determination of the given two alkaloids in FU and FT powder, Most studies mainly focused on the determination of several other alkaloids present in high contents. Liu et al developed a method to determine the two alkaloids simultaneously from alkaloid extracts of Bulbus Fritillaria in rat plasma [ 30 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…There are several reports on assaying peimine and peiminine in Bulbus Fritillaria [ 18 , 19 , 23 , 31 ], but no analytical method was developed for the simultaneous determination of the given two alkaloids in FU and FT powder, Most studies mainly focused on the determination of several other alkaloids present in high contents. Liu et al developed a method to determine the two alkaloids simultaneously from alkaloid extracts of Bulbus Fritillaria in rat plasma [ 30 ].…”
Section: Resultsmentioning
confidence: 99%
“…Several analytical methods have been used in the qualitative or quantitative determination of peimine and peiminine [ 18 ], including ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS), rapid liquid chromatography tandem mass spectrometry (UPLC-TQ/MS), gas chromatography coupled with flame ionization detector (GC-FID), electronic ionization mass spectrometry (EI-MS), high-performance liquid chromatography coupled with ultra-violet visible detector (HPLC-UV), capillary electrophoresis (CE), and HPLC coupled with evaporative light scattering detection (HPLC-ELSD) [ 19 , 20 , 21 , 22 , 23 ]. Among these methods, HPLC-UV is not suitable for a large number of sample analyses; the CE and HPLC-ELSD methods show a lack of sensitivity.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, OST also betters cognitive function and improves neuronal recovery [ 6 , 13 ]. However, the poor water solubility and the low bioavailability [ 14 , 15 ] hinder the clinical application of OST for the treatment of neurologic disorders. Furthermore, OST is pH-sensitive [ 16 ], which also affects its application.…”
Section: Introductionmentioning
confidence: 99%
“…In the Chinese Pharmacopeia, these eighteen incompatible herbal pairs are prohibited in prescriptions, though several classical prescriptions used in clinic contain incompatible herbal pairs, such as Gansui-Banxia Decoction, Haizao-Yuhu Decoction, Gan-Zao Decoction, etc. (Shen et al, 2013;Ma et al, 2016;Yu et al, 2018). This confused situation is largely due to the ambiguity of the conditions of occurrence and interaction mechanisms of these incompatibilities.…”
Section: Introductionmentioning
confidence: 99%