Darunavir and Ritonavir are amongst the most useful antiretroviral drugs worldwide for treating
AIDS (acquired immune deficiency syndrome). This review discussed and summarized the various
analytical techniques used in the qualitative and quantitative analysis of darunavir and ritonavir, protease
inhibitors (PIs), which have gained importance as antiretroviral drugs. The importance and use of
chromatographic techniques for the estimation of darunavir and ritonavir are also discussed herein. This
review highlights the various advanced analytical techniques such as spectroscopic, chromatographic,
electrophoresis, X-ray powder diffraction and their corresponding methods.