Development of a wireless swallowable capsule with potentiostatic electrochemical sensor for gastrointestinal track investigation

Caffrey, Colm Mc; Twomey, Karen; Ogurtsov, Vladimir I.

doi:10.1016/j.snb.2015.04.063

Cited by 40 publications

(31 citation statements)

References 19 publications

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“…While there are significant challenges to overcome, ingestible electrochemical sensors show promise in detecting various physiologically relevant analytes in the GI tract. An ingestible electrochemical sensor has been developed and used to perform voltammetric measurements in human stool . Stable measurements were shown across different samples, but the measurements are not specific due to lack of a biorecognition layer.…”

Section: Capsules For Robotic Sensingmentioning

confidence: 99%

Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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Since the advent of ingestible temperature sensors and capsule endoscopes, rapid advances in electronics, robotics, nanotechnology, and material sciences have opened the door for the development of novel medical ingestible robots. The untethered robots provide direct, non-invasive access to the entire gastrointestinal (GI) tract. Furthermore, the tissues, gases, and fluids of the gastrointestinal lumen contain a multitude of biomarkers indicative of gut diseases and health. Ingestible medical robots equipped with advanced imaging and sensing techniques can enable the diagnosis and monitoring of diseases, while providing a better pathophysiological understanding of gastrointestinal disorders. In addition, various robotic actuation mechanisms in the macro-and microscale can realize enhanced drug delivery and surgical interventions for the treatment of diseases. In this paper, an overview of recent advances in ingestible robots toward imaging, sensing, drug delivery, and surgical applications in the GI tract is provided. Key challenges and strategies for the development of novel ingestible robots and future directions of ingestible robots toward precision medicine are also discussed.

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Section: Capsules For Robotic Sensingmentioning

confidence: 99%

Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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“…Numerous advantages have been obtained such as direct and rapid measurement, instrumental simplicity, accuracy, stability, high sensitivity and selectivity, minimally invasive implantable devices and others (Jackowska and Krysinski, 2013; Wang, 2008; Zhang et al, 2014). In the last two decades, some devices have been proposed for use in vivo including electrochemical sensors (Caffrey et al, 2015;Grant et al, 2001;Gyetvai et al, 2009;Harreither et al, 2013;Hurst and Clark, 2003;Jacobs et al, 2011;Liu et al, 2012aLiu et al, , 2015Ragones et al, 2015;Shao et al, 2013;Swamy and Venton, 2007;Wang et al, 2001;Zhang et al, 2007); and biosensors (Abel and von Woedtke, 2002;Chai et al, 2013;Deng et al, 2008;Edagawa et al, 2014;Lin et al, 2013;Lowry and Fillenz, 2001;Lu et al, 2013;Pohanka et al, 2009;Ren et al, 2013;Ricci et al, 2007;Santos et al, 2015a;Tian et al, 2005;Yu et al, 2011aYu et al, , 2011bZhang et al, 2004;Zhu et al, 2009). In this context, recently, graphene has also been used in electrochemical sensors (Arvand and Ghodsi, 2013;Manibalan et al, 2015;Zhu et al, 2011) and biosensors (Gu et al, 2014(Gu et al, , 2012 for in vivo applications.…”

Section: Biosensors Based On Graphene Applied To In Vivo Analysismentioning

confidence: 99%

The application of graphene for in vitro and in vivo electrochemical biosensing

Janegitz

Silva

Wong

et al. 2017

Biosensors and Bioelectronics

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Advances in analysis are required for rapid and reliable clinical diagnosis. Graphene is a 2D material that has been extensively used in the development of devices for the medical proposes due to properties such as an elevated surface area and excellent electrical conductivity. On the other hand, architectures have been designed with the incorporation of different biological recognition elements such as antibodies/antigens and DNA probes for the proposition of immunosensors and genosensors. This field presents a great progress in the last few years, which have opened up a wide range of applications. Here, we highlight a rather comprehensive overview of the interesting properties of graphene for in vitro, in vivo, and point-of-care electrochemical biosensing. In the course of the paper, we first introduce graphene, electroanalytical methods (potentiometry, voltammetry, amperometry and electrochemical impedance spectroscopy) followed by an overview of the prospects and possible applications of this material in electrochemical biosensors. In this context, we discuss some relevant trends including the monitoring of multiple biomarkers for cancer diagnostic, implantable devices for in vivo sensing and, development of point-of-care devices to real-time diagnostics.

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“…Some attempts have been made to integrate sensors for the detection of these substances in 27 CE devices. Up to now, these sensors have utilized either electrochemical 148,149 or optical 150-152 methods. 28…”

mentioning

confidence: 99%

“…The single electrochemical sensing capsule 148,149 incorporates a multi-electrode sensor with onboard potentiostatic 30 circuits to enable cyclic and pulsed voltammetry of the gastrointestinal fluid surrounding the capsule. To date, these 31 capsules have been tested only in vitro using fecal water to demonstrate repeatable and reliable measurement.…”

mentioning

confidence: 99%