Development of active edible films made from banana starch and curcumin-loaded nanoemulsions

Sánchez, Leidy T.; Pinzón, Magda I.; Villa, Cristian C.

doi:10.1016/j.foodchem.2021.131121

Cited by 61 publications

(31 citation statements)

References 53 publications

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“…The highest and lowest amylose contents were obtained by Mzuzu and Bukoba, respectively. Banana starch with high amylose content could be considered to make edible films ( Sanchez, Pinzon, & Villa, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Structural, physicochemical and rheological properties of starches isolated from banana varieties (Musa spp.)

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Structural, physicochemical and rheological properties of starches isolated from banana varieties (Musa spp.)

et al. 2022

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“…In contrast, the Peppas-Sahlin model describes the drug release from CS/DCX-PLGA NPs.The Peppas-Sahlin model is based on the combination of diffusion and erosion of the nanoparticle matrix. In order to further elucidate the kinetics model, a few more parameters were examined[62]. The diffusional exponent values (n or m) regarding the release kinetics from the nanoparticles were computed.…”

mentioning

confidence: 99%

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

Ünal¹,

Doğan²,

Aktaş³

2022

Beilstein J. Nanotechnol.

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Intestinal cancers are the third most lethal cancers globally, beginning as polyps in the intestine and spreading with a severe metastatic tendency. Chemotherapeutic drugs used in the treatment of intestinal tumors are usually formulated for parenteral administration due to poor solubility and bioavailability problems. Pharmaceutically, clinical failure due to a drug’s wide biodistribution and non-selective toxicity is one of the major challenges of chemotherapy. In addition, parenteral drug administration in chronic diseases that require long-term drug use, such as intestinal tumors, is challenging in terms of patient compliance and poses a burden in terms of health economy. Especially in the field of chemotherapy research, oral chemotherapy is a subject that has been intensively researched in recent years, and developments in this field will provide serious breakthroughs both scientifically and socially. Development of orally applicable nanodrug formulations that can act against diseases seen in the distant region of the gastrointestinal tract (GIT), such as intestinal tumor, brings with it a series of difficulties depending on the drug and/or GIT physiology. The aim of this study is to develop an oral nanoparticle drug delivery system loaded with docetaxel (DCX) as an anticancer drug, using poly(lactic-co-glycolic acid) (PLGA) as nanoparticle material, and modified with chitosan (CS) to gain mucoadhesive properties. In this context, an innovative nanoparticle formulation that can protect orally administered DCX from GIT conditions and deliver the drug to the intestinal tumoral region by accumulating in mucus has been designed. For this purpose, DCX-PLGA nanoparticles (NPs) and CS/DCX-PLGA NPs were prepared, and their in vitro characteristics were elucidated. Nanoparticles around 250–300 nm were obtained. DCX-PLGA NPs had positive surface charge with CS coating. The formulations have the potential to deliver the encapsulated drug to the bowel according to the in vitro release studies in three different simulated GIT fluids for approximately 72 h. Mucin interaction and penetration into the artificial mucus layer were also investigated in detail, and the mucoadhesive and mucus-penetration characteristics of the formulations were examined. Furthermore, in vitro release kinetic studies of the NPs were elucidated. DCX-PLGA NPs were found to be compatible with the Weibull model, and CS/DCX-PLGA NPs were found to be compatible with the Peppas–Sahlin model. Within the scope of in vitro cytotoxicity studies, the drug-loaded NPs showed significantly higher cytotoxicity than a DCX solution on the HT-29 colon cell line, and CS/DCX-PLGA showed the highest cytotoxicity (p < 0.05). According to the permeability studies on the Caco-2 cell line, the CS/DCX-PLGA formulation increased permeability by 383% compared to free DCX (p < 0.05). In the light of all results, CS/DCX-PLGA NPs can offer a promising and innovative approach as an oral anticancer drug-loaded nanoformulation for intestinal tumors.

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“…[63][64][65] Several strategies can be used in order to improve those properties, such as the inclusion of bioactive molecules, especially the ones with high hydrophobic nature, that allow a reduction of the water vapour permeability through the film. 66 The most common polysaccharides used in the development of edible films and coatings are starch, cellulose, pectin, pullulan, alginates, chitosan and some gums. 67 Starch is one of the most common polysaccharides in nature, second only to cellulose, as it is used by plants as an energy reserve.…”

Section: Polymeric Matrix Used In Bioactive Food Packagingmentioning

confidence: 99%

Bioactive food coating: A review

et al. 2022

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Bioactive food packaging is a trend in food packaging science and technology, which is focused on the consumer's health benefits provided by the edible polymeric packaging and the inclusion of bioactive molecules of natural origin, probiotic microorganism and/or prebiotic molecules. Several types of edible films and bioactive molecules have been used in order to create bioactive molecules. In some cases, mechanical and barrier properties of the edible film are enhanced by the bioactive molecule. Likewise, inclusion of probiotics could also lead to enhanced properties of the film. This review will be useful to understand the different components and characteristics of the different types of bioactive films.

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Development of active edible films made from banana starch and curcumin-loaded nanoemulsions

Cited by 61 publications

References 53 publications

Structural, physicochemical and rheological properties of starches isolated from banana varieties (Musa spp.)

Structural, physicochemical and rheological properties of starches isolated from banana varieties (Musa spp.)

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

Bioactive food coating: A review

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