Development of acute ischemic stroke in a patient with acute respiratory distress syndrome (ARDS) resulting from H1N1 pneumonia

Burad, Jyoti; Bhakta, Pradipta; George, Jojy; Kiruchennan, Sinna

doi:10.1016/j.aat.2012.02.002

Cited by 12 publications

(10 citation statements)

References 11 publications

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“…These apparently disparate diseases share physiological and clinical associations. Burad et al ( 2012 ) found that acute respiratory syndrome in pneumonia patients leads to strong systemic ischemia that may in turn develop into acute encephalopathy. This finding has been further confirmed in a very large (5.6 million cases) epidemiological risk factor study of the group of Bell in the US (Rincon et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Comorbidity Networks in Cardiovascular Diseases

et al. 2020

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Background: Cardiovascular diseases are the leading causes of mortality worldwide. One reason behind this lethality lies in the fact that often cardiovascular illnesses develop into systemic failure due to the multiple connections to organismal metabolism. This in turn is associated with co-morbidities and multimorbidity. The prevalence of coexisting diseases and the relationship between the molecular origins adds to the complexity of the management of cardiovascular diseases and thus requires a profound knowledge of the genetic interaction of diseases. Objective: In order to develop a deeper understanding of this phenomenon, we examined the patterns of comorbidity as well as their genetic interaction of the diseases (or the lack of evidence of it) in a large set of cases diagnosed with cardiovascular conditions at the national reference hospital for cardiovascular diseases in Mexico. Methods: We performed a cross-sectional study of the National Institute of Cardiology. Socioeconomic information, principal diagnosis that led to the hospitalization and other conditions identified by an ICD-10 code were obtained for 34,099 discharged cases. With this information a cardiovascular comorbidity networks were built both for the full database and for ten 10-years age brackets. The associated cardiovascular comorbidities modules were found. Data mining was performed in the comprehensive ClinVar database with the disease names (as extracted from ICD-10 codes) to establish (when possible) connections between the genetic associations of the genetic interaction of diseases. The rationale is that some comorbidities may have a stronger genetic origin, whereas for others, the environment and other factors may be stronger. Results: We found that comorbidity networks are highly centralized in prevalent diseases, such as cardiac arrhythmias, heart failure, chronic kidney disease, hypertension, and ischemic diseases. Said comorbidity networks are actually modular on their connectivity. Modules recapitulate physiopathological commonalities, e.g., ischemic diseases clustering together. This is also the case of chronic systemic diseases, of congenital malformations and others. The genetic and environmental commonalities behind some of the relations in these modules were also found by resorting to clinical genetics databases and functional pathway enrichment studies. Conclusions: This methodology, hence may allow the clinician to look up for non-evident comorbidities whose knowledge will lead to improve therapeutically designs. By continued and consistent analysis of these types of patterns, we envisaged that it may be possible to acquire, strong clinical and basic insights that may further our advance toward a better understanding of cardiovascular diseases as a whole. Hopefully these may in turn lead to further development of better, integrated therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Comorbidity Networks in Cardiovascular Diseases

et al. 2020

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“…One case of multiple strokes occurred in a young woman with disseminated intravascular coagulation who was critically ill. 72 The other case occurred in a 50-year-old woman with ARDS secondary to influenza A(H1N1) who developed multiple strokes in the territory of the right middle cerebral artery. 73 There may be indirect evidence of an association between influenza and CVAs, but data from influenza vaccination and neuraminidase inhibitors are conflicting. 74,75 One case-control study in France found that the risk of stroke was reduced in subjects vaccinated in that year compared to those not vaccinated (OR 0.50, 95% CI 0.26-0.94).…”

Section: Strokementioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

337

308

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Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra‐pulmonary complications of influenza infection, using organ‐specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra‐pulmonary complications is critical to determining the true burden of influenza infection and initiating organ‐specific supportive care.

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“…A total of 115 articles were initially retrieved, but eleven of them were eliminated according to our exclusion criteria. Finally, considering our inclusion criteria, only 104 articles (1636 patients) were included and divided into two groups, according to the origin of neurological complications: influenza vaccine‐related (287 patients) or viral infection‐related (1349 patients) (Tables S1 and S2) . The main characteristics of patients are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

Neurological events related to influenza A (H1N1) pdm09

Cárdenas

Soto-Hernández

Díaz-Alba

et al. 2014

Influenza Resp Viruses

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ObjectivesTo review neurological complications after the influenza A (H1N1) pdm09, highlighting the clinical differences between patients with post-vaccine or viral infection.DesignA search on Medline, Ovid, EMBASE, and PubMed databases using the keywords “neurological complications of Influenza AH1N1” or “post-vaccine Influenza AH1N1.”SettingOnly papers written in English, Spanish, German, French, Portuguese, and Italian published from March 2009 to December 2012 were included.SampleWe included 104 articles presenting a total of 1636 patient cases. In addition, two cases of influenza vaccine-related neurological events from our neurological care center, arising during the period of study, were also included.Main outcome measuresDemographic data and clinical diagnosis of neurological complications and outcomes: death, neurological sequelae or recovery after influenza A (H1N1) pdm09 vaccine or infection.ResultsThe retrieved cases were divided into two groups: the post-vaccination group, with 287 patients, and the viral infection group, with 1349 patients. Most patients in the first group were adults. The main neurological complications were Guillain-Barre syndrome (GBS) or polyneuropathy (125), and seizures (23). All patients survived. Pediatric patients were predominant in the viral infection group. In this group, 60 patients (4.7%) died and 52 (30.1%) developed permanent sequelae. A wide spectrum of neurological complications was observed.ConclusionsFatal cases and severe, permanent, neurological sequelae were observed in the infection group only. Clinical outcome was more favorable in the post-vaccination group. In this context, the relevance of an accurate neurological evaluation is demonstrated for all suspicious cases, as well as the need of an appropriate long-term clinical and imaging follow-up of infection and post-vaccination events related to influenza A (H1N1) pdm09, to clearly estimate the magnitude of neurological complications leading to permanent disability.

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Development of acute ischemic stroke in a patient with acute respiratory distress syndrome (ARDS) resulting from H1N1 pneumonia

Cited by 12 publications

References 11 publications

Comorbidity Networks in Cardiovascular Diseases

Comorbidity Networks in Cardiovascular Diseases

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Neurological events related to influenza A (H1N1) pdm09

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