Development of alginate and gelatin-based pleural and tracheal sealants

Rationally Designed Anisotropic and Auxetic Hydrogel Patches for Adaptation to Dynamic Organs

“…[57,58] Other studies have used hydrogel-based plugs for the treatment of lung punctures; for example, Gasek et al developed an adhesive hydrogel composed of dopaminefunctionalized alginate methacrylate and gelatin as a pleural sealant. [59] In these rat models with puncture wounds induced through a needle (18 G) injury, the restoration of tidal ventilation pressure was not quantified and there was no comparison with other sealants such as fibrin glue. Matoba et al developed a polyglycolic acid sheet and alginate gel to reduce pulmonary air leaks.…”

“…Of note, we did not test non-auxetic patches as a control, as we already established ex vivo that an auxetic patch is desirable for implanting over the lung and because fibrin alone mimicked the sealing effect of blood pleurodesis or simple hydrogel-based patches in previous studies. [57][58][59][60] In these experiments, separate rats (n = 3 per treatment) were tested under both physiological ventilation (tidal ventilation volume of 7.5 ml kg −1 ) and hyperventilation states (tidal ventilation volume of 12.5 ml kg −1 ). Figure 6D shows the results of the dilation ventilation pressure (measured using a pressure gauge attached to the airway outlet) before and after injury and treatment.…”

Fabrication and Characterization of Bioactive Gelatin–Alginate–Bioactive Glass Composite Coatings on Porous Titanium Substrates

“…On the other hand, the biocompatibility of these polymeric materials has not been tested since, as previously mentioned, it has been widely proven by other authors in both in vitro and in vivo experiments for different tissues, − including the bone and the cartilage. − …”

“…On the other hand, different approaches have been tested to develop new biomaterials as cartilage tissue replacement, ,− in particular, and tissue engineering, in general. − Polymers and polymeric composites are the most commonly used materials considered for this application − due to their biocompatibility and tunable properties, − which enable development of their chemical structure or composition according to the final aim. In this sense, among naturally occurring polymers, gelatin and alginate stand out for the possibility of tuning their mechanical properties thanks to the degree of cross-linking. , Their biocompatibility have been widely investigated in different in vitro and in vivo experiments for diverse tissues, − including the bone and the cartilage. − In addition, they form hydrogels that allow the easy preparation of composites, − for example, bioactive glasses, , for the improvement of their osseointegration capacity. , …”

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

“…[125][126][127] It is a common strategy to prepare hydrogels for wound treatment by Schiff base reaction between gelatin with oxidized polysaccharides. 84,86,[128][129][130] In addition, catechol [130][131][132][133][134] /pyrogallol [135][136][137] are introduced into gelatinbased hydrogels for further adhesion enhancement, and methacrylate gelatin (GelMA) hydrogels are preferred for convenience in some cases. 76,126,134,[138][139][140][141] Building on the above methods, researchers have recently developed a series of excellent wound management strategies.…”