Development of alginate gel beads with a potential use in the treatment against acute lead poisoning

Tahtat, Djamel; Bouaicha, Malika Nawel; Benamer, Samah; Nacer-Khodja, Assia; Mahlous, Mohamed

doi:10.1016/j.ijbiomac.2017.07.137

Cited by 21 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the results shown in Figure S12 , we come to know that with the increase of n (LA): n (IDA), the Pb 2+ chelating capacity of P(LA- co -IDA)s is gradually decreased from 1.80 mg·g −1 of IDA8 to 0.33 mg·g −1 of IDA128. The datum is similar to ( Tahtat et al., 2017 ; El-Ashgar et al., 2017 ) or higher than ( Liu et al., 2020 ; Blicharska et al., 2018 ) that of the reported polymeric (or M w over 1,200 Da) Pb 2+ chelators using IDA or other substances as functional groups. Importantly, this level of chelating capacity is suitable for a potential biomedical chelating agent as a treatment drug for chelating and removing lead ions in vivo because the threshold of lead poisoning that requires treatment is 10 μg·dL −1 ( Balasubramanian et al., 2020 ), and the corresponding dosage of small molecule chelating drugs is as low as 30 mg·kg −1 body weight per day ( Safi et al., 2019 ).…”

Section: Resultssupporting

confidence: 81%

“…However, the traditional small molecule-type chelating agents have obvious disadvantages, such as large dosage, high toxicity, and non-biodegradation ( Bretti et al., 2017 ; He et al., 2019a , 2019b ). Thus, it is of great practical significance to develop polymeric chelators with biocompatibility, biodegradability, and long-term efficacy ( Tahtat et al., 2017 ; Bretti et al., 2019 ). As far as we know, to date, there have been no reports on such chelating agents based on PLA materials.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Controllable preparation and performance of bio-based poly(lactic acid-iminodiacetic acid) as sustained-release Pb2+ chelating agent

et al. 2021

View full text Add to dashboard Cite

Summary The bio-based lactic acid (LA) and the common metal ion chelating agent iminodiacetic acid (IDA) are used to design and prepare a polymeric sustained-release Pb 2+ chelating agent by a brief one-step reaction. After the analysis on theoretical calculation for this reaction, poly(lactic acid-iminodiacetic acid) [P(LA- co -IDA)] with different monomer molar feed ratios is synthesized via direct melt polycondensation. P(LA- co -IDA) mainly has star-shaped structure, and some of them have two-core or three-core structure. Thus, a possible mechanism of the polymerization is proposed. The degradation rate of P(LA- co -IDA)s can reach 70% in 4 weeks. The change of IDA release rate is consistent with the trend of the degradation rate, and the good Pb 2+ chelating performance is confirmed. P(LA- co -IDA) is expected to be developed as a lead poisoning treatment drug or Pb 2+ adsorbent in the environment with long-lasting effect, and this research provides a new strategy for the development of such drugs.

show abstract

Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Controllable preparation and performance of bio-based poly(lactic acid-iminodiacetic acid) as sustained-release Pb2+ chelating agent

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In hydrated acidic alginate gels the intermolecular hydrogen-bonding interactions are supposed to be partly weakened. , Consequently, fluid uptake into the ALG matrix is allowed, , and moderate swelling of the ALG beads occurs. The swelling capacity of ALG beads in SGF thus primarily depends on the ionic strength of H + , allowing replacement of the metal ions and the formation of acidic ALG gels.…”

Section: Resultsmentioning

confidence: 99%

Interaction Pathways and Structure–Chemical Transformations of Alginate Gels in Physiological Environments

Urbanová

Pavelková²,

Czernek

et al. 2019

Biomacromolecules

View full text Add to dashboard Cite

The remarkably diverse affinity of alginate (ALG) macromolecules for polyvalent metal ions makes cross-linked alginate gels an outstanding biomaterial. Surprisingly, however, very little is known about their interactions and structural transformations in physiological environments. To bridge this gap, we prepared a set of ALG gels cross-linked by various ions and monitored their structural changes at different media simulating gastric and intestinal fluids and cellular environments. For these studies, we used multinuclear solid-state NMR (ss-NMR) spectroscopy, which revealed a range of competitive ion-exchange and interconversion reactions, the rate of which strongly depended on the nature of the cross-linking metal ions. Depending on the environment, ALG chains adopted different forms, such as acidic (hydro)gels stabilized by strong hydrogen bonds, and/or weakly cross-linked Na/H-gels. Simultaneously, the exchanged polyvalent ions extensively interacted with the environment even forming in some cases insoluble phosphate microdomains directly deposited in the ALG bead matrix. The extent of the transformations and incorporation of secondary phases into the alginate beads followed the size and electronegativity of the cross-linking ions. Overall, the applied combination of various macroscopic and biological tests with multinuclear ss-NMR revealed a complex pathway of alginate beads transformations in physiological environments.

show abstract

“…For patients suffering from a lead poisoning crisis and having an urgent requirement for in vivo lead removal, these highly efficient adsorbents unavoidably cause the reaction of hemolysis, immune rejection, and secondary poisoning. [ 27 ] That means conventional adsorbents for environmental purification meet an obstacle to lead removal in the human body. Hence, new adsorbents with bio‐safe features are in urgent need.…”

Section: Introductionmentioning

confidence: 99%

Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Cao

Dong

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Emerging adsorption technology shows great potential for Pb 2+ removal in the human body because of its high adsorption efficiency and easy operation. However, biosafety concerns in the human body limit the development of adsorbents in integrated lead removal for acute poisoning in humans from the gastrointestinal tract and even the blood. In this work, highly bio-safe and natural saccharomyces cerevisiae cells are immobilized on the interworking natural regenerated cellulose nanofibers network for integrated lead removal in the human body. High intrinsic biosafety of the aerogel is guaranteed due to the biocompatibility of aerogel composition and the absence of crosslinking substances. Attributing to the porous structure of cellulose nanofibrous scaffolds, saccharomyces cerevisiae cells are protected from shedding, and considerable loading sites for saccharomyces cerevisiae cells are ensured. Simultaneously, abundant functional groups on the saccharomyces cerevisiae cells exhibit superior adsorption ability with a saturated adsorption capacity of lead ions as high as 107 mg g −1 in the aquatic environment. After adsorption, Pb 2+ concentration decreases from 879.70 to 248.53 µg L −1 in the intestinal phase and from 400 to 186.29 µg L −1 (within a safe level) in blood, providing an attractive strategy for detoxification of integrated lead in the human body.

show abstract

Development of alginate gel beads with a potential use in the treatment against acute lead poisoning

Cited by 21 publications

References 28 publications

Controllable preparation and performance of bio-based poly(lactic acid-iminodiacetic acid) as sustained-release Pb2+ chelating agent

Controllable preparation and performance of bio-based poly(lactic acid-iminodiacetic acid) as sustained-release Pb2+ chelating agent

Interaction Pathways and Structure–Chemical Transformations of Alginate Gels in Physiological Environments

Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Contact Info

Product

Resources

About