Development of an amplified luminescent proximity homogeneous assay for the detection of sulfonamides in animal‐derived products

Abstract

Sulfonamides (SAs) are a group of synthetic chemotherapeutics with a common p-aminobenzene sulfonamide moiety. They have been widely used as veterinary antibiotic drugs to prevent bacterial infectious diseases and promote animal husbandry and fish farming since last century (Liu et al., 2016). The widespread use of SAs in animal husbandry, and noncompliance with withdrawal time, can enrich chemical residues in animal-derived foods. Furthermore, the SAs residues in foods can create potential human health hazards to cause thyroid follicular tumors, allergic reactions, and antibiotic resistance. To ensure food safety for consumers, European Union and China have set the MRL for edible animal products including meat and milk to 100 ng/ml for total SAs content, and the United