Development of an amplified nanostructured electrochemical sensor for the detection of cefixime in pharmaceuticals and biological samples

Darabi, Rozhin; Shabani-Nooshabadi, Mehdi

doi:10.1016/j.jpba.2022.114657

Cited by 11 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oxidation signal of 200 µM lorazepam was recorded at surface of PE (Figure 2a), ZnO-NPs/PE (Figure 2b), HMImCl/PE (Figure 2c) and HMImCl/ZnO-NPs/PE (Figure 2d), respectively. As can be seen, a linear relation between oxidation signals of 300 µM lorazepam and  1/2 with equation I = 2.5907 1/2 + 3.4097 (R 2 = 0.9916) that confirm diffusion process [52][53][54][55] to lorazepam oxidation at surface of HMImCl/ZnO-NPs/PE. On the other hand, positive shift in oxidation signal of lorazepam with increase in scan rate confirm kinetic limitation in redox reaction of this drug.…”

Section: Electrochemical Investigationsmentioning

confidence: 58%

ZnO/1-hexyl-3-methylimidazolium chloride paste electrode, highly sensitive lorazepam sensor

Chenarani

Ebrahimi

Arabali

et al. 2023

J. Electrochem. Sci. Eng.

View full text Add to dashboard Cite

The measurement of pharmaceutical compounds in biological fluids is considered an effective way to evaluate their effectiveness. On the other hand, lorazepam is a drug with good efficiency in treatment and some side effects, which measurement is very important. In this study, the ZnO nanoparticle was synthesized as an electrocatalyst by chemical precipitation method. In continuous a simple modification on paste electrode (PE) by ZnO nanoparticle (ZnO-NPs) and 1-hexyl-3-methylimidazolium chloride (HMImCl) was made and new sensor was used for sensing of lorazepam. The HMImCl/ZnO-NPs/PE showed catalytic behavior on oxidation signal of lorazepam and improved its signal about 2.17 times compared to unmodified PE. On the other hand, oxidation signal of lorazepam was reduced about 110 mV at surface of HMImCl/ZnO-NPs/PE compare to unmodified PE that confirm accelerating the electron exchange process after modification of sensor by HMImCl and ZnO-NPs as powerful catalysts. The HMImCl/ZnO-NPs/PE was used for monitoring of lorazepam in water and injection samples and results showed recovery data 98.5 to 103.5 % that are acceptable for a new sensor.

show abstract

Section: Electrochemical Investigationsmentioning

confidence: 58%