Development of an analytical method to confirm toxic trimethylated tin in human urine

Suzuki, Yoshihiro; Endo, Yuichi; Ogawa, Masanori; Kim, Yangho; Onda, Nobuhiko; Yamanaka, Kazuhiro

doi:10.1016/j.jchromb.2008.04.032

Cited by 15 publications

(8 citation statements)

References 13 publications

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“…To get the best resolution for the four organotin compounds in a shorter analysis time, various compositions of mobile phase were investigated in this paper. Since DBT and DPhT have similar polarity, it is difficult to separate them in simple mobile phase composition including methanol/ammonium formate/formic acid , methanol/ammonium acetate/acetic acid , etc. The best results were obtained with a gradient elution by a mobile phase consisting of methanol/10% acetic acid (adjusted to pH = 3.0 by triethylamine), using Pursuit 5μ‐C 18 column (250 × 4.6 mm id, Varian Technologies, USA), and the flow rate of mobile phase was 0.50 mL/min.…”

Section: Resultsmentioning

confidence: 99%

Fast and effective low‐temperature freezing extraction technique to determine organotin compounds in edible vegetable oil

Liu

Wan

et al. 2016

J of Separation Science

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Most organotin compounds that have been widely used in food packaging materials and production process show serious toxicity effects to human health. In this study, a simple and low-cost method based on high-performance liquid chromatography with inductively coupled plasma mass spectrometry for the simultaneous determination of four organotins in edible vegetable oil samples was developed. Four organotins including dibutyltin dichloride, tributyltin chloride, diphenyltin dichloride, and triphenyltin chloride were simultaneously extracted with methanol using the low-temperature precipitation process. After being concentrated, the extracts were purified by matrix solid-phase dispersion using graphitized carbon black. The experimental parameters such as extraction solvent and clean-up material were optimized. To evaluate the accuracy of the new method, the recoveries were investigated. In addition, a liquid chromatography with tandem mass spectrometry method was also proposed for comparison. The procedures of extracting and purifying samples for the analysis were simple and easy to perform batch operations, also showed good efficiency with lower relative standard deviation. The limits of detection of the four organotins were 0.28-0.59 μg/L, and the limits of quantification of the four organotins were 0.93-1.8 μg/L, respectively. The proposed method was successfully applied to the simultaneous analysis of the four organotins in edible vegetable oil. Some analytes were detected at the level of 2.5-28.8 μg/kg.

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Section: Resultsmentioning

confidence: 99%

Fast and effective low‐temperature freezing extraction technique to determine organotin compounds in edible vegetable oil

Liu

Wan

et al. 2016

J of Separation Science

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“…To the best of our knowledge, this is the only epidemiological study that addressed the levels of methyltins in human urine. The few remaining studies refer to acute poisoning events (Gui-bin et al 2000a, b;Suzuki et al 2008;Yoo et al 2007). …”

Section: Urinementioning

confidence: 99%

Pollutant Diseases, Remediation and Recycling

2013

Environmental Chemistry for a Sustainable World

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“…In this study, Tetraphenyltin [ were studied as target analytes because of its wide usage in insecticides, fungicides, bactericides, acaricides, preservatives, catalysts, stabilizers for PVC, antifouling paints, water repellents, fire retardants for woolen and cotton fabrics, moth repellants of textiles, disinfectors of hospitals, clothing and UV-oxidation resistance stabilizers, therefore found in numerous compartments such as water, plastic, textile and agriculture products etc. [7][8][9][10][11][12][13]. As a result, there is a variety of pathways for their entry into the environment and have long-term persistence in the environment.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, there is a variety of pathways for their entry into the environment and have long-term persistence in the environment. Their extreme toxicity and brutal effects on both mammals [14] and marine organism [15] including humans as well as their high bioaccumulation prospect have led to the urgency in controlling the pollution levels of phenyltin species at low concentration levels. In addition, long-term exposure to phenyltin derivatives can lead to anomalies in DNA mutation and human red blood cells [16].…”

Section: Introductionmentioning

confidence: 99%

Development of a Fabric Phase Sorptive Extraction-High Performance Liquid Chromatography-Ultraviolet Detection Method for the Analysis of Phenyltin Compounds in Environmental Water and Canned Food Samples

Heena¹,

Malik²,

Kabir³

et al. 2018

Preprint

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This paper reports a novel fabric phase sorptive extraction-high performance liquid chromatography-ultra violet detection (FPSE-HPLC-UV) method for the simultaneous extraction and analysis of four phenyltin derivatives that include triphenyltin hydroxide, triphenyltin acetate, triphenyltin chloride and tetraphenyltin in environmental water (agricultural waste water and municipal waste water) and canned food samples. The selected analytes were well resolved by Waters Nova pack C18 column (3.9 x 150 mm, 4 µm particle size) in isocratic elution mode within 15 minutes. The new microextraction media has been analytically evaluated using phenyltin derivatives as model compounds. The factors affecting the extraction efficiency of FPSE have been evaluated and the optimum extraction conditions were determined. Under these optimum conditions, the limits of detection (LODs) for sol-gel C18 coated fabric phase sorptive extraction (FPSE) media in combination with HPLC-UV for the analysis of the phenyltin derivatives were in the range of 10-100 ng/mL with high precision (low relative standard deviation) at 10 ng/mL concentration with good absolute recoveries. To the best of our knowledge, this is the first FPSE extraction procedure applied to environmental water and canned food samples for the simultaneous determination of phenyltin derivatives and could be readily adopted as a rapid and robust green analytical tool for routine environmental and food analytical laboratories.

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Development of an analytical method to confirm toxic trimethylated tin in human urine

Cited by 15 publications

References 13 publications

Fast and effective low‐temperature freezing extraction technique to determine organotin compounds in edible vegetable oil

Fast and effective low‐temperature freezing extraction technique to determine organotin compounds in edible vegetable oil

Pollutant Diseases, Remediation and Recycling

Development of a Fabric Phase Sorptive Extraction-High Performance Liquid Chromatography-Ultraviolet Detection Method for the Analysis of Phenyltin Compounds in Environmental Water and Canned Food Samples

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