Development of an autofluorescent probe for brain cancer: probe characterization thanks to phantom studies

Abstract

Glioblastoma are brain tumors currently incurable, however, optimized treatment gives better prognosis and quality of life. In case of surgical treatment, there is still need to help surgeons to determine whether a tissue is tumorous or not. Within the framework of the design of a new autofluorescence probe for this issue, optically calibrated gel phantoms have been developed using "tumorous" inclusions in a "healthy" environment. Depending on "tumor" shape, size and localization, the sensitivity of the probe is evaluated. The probe sensitivity for fluorescence spectroscopy will be presented. The probe configuration is also taken into account and compared to simulated results.

Optical phantoms with variable properties and geometries for diffuse and fluorescence optical spectroscopy

“…33 Detailed results will be published soon. In the end, the benefits of a phantom with variable optical parameters and adaptable geometries were shown for detection-probe characterization.…”