Development of an Early Prediction Model for Subarachnoid Hemorrhage With Genetic and Signaling Pathway Analysis

Abstract

Subarachnoid hemorrhage (SAH) is devastating disease with high mortality, high disability rate, and poor clinical prognosis. It has drawn great attentions in both basic and clinical medicine. Therefore, it is necessary to explore the therapeutic drugs and effective targets for early prediction of SAH. Firstly, we demonstrate that LCN2 can effectively intervene or treat SAH from the perspective of cell signaling pathway. Next, three potential genes that we explored have been validated by manually reviewed experimental evidences. Finally, we turn out that the SAH early ensemble learning predictive model performs better than the classical LR, SVM, and Naïve-Bayes models.

ASTM: Developing the web service for anthrax related spatiotemporal characteristics and meteorology study

“…where k represents the lag order and is the error term. We use the F-test [23,[31][32][33][34][35][36][37][38][39] to verify the null hypothesis (Eq. ( 6)).…”

Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis

“…In summary, our study not only identified the brain regions affected by secondary neurological dysfunction after IVH stimulation from a 3D perspective but also allows for the further investigation of driving cell types and molecular pathways, which might benefit the construction of translational intervention strategies for secondary brain injuries after IVH at the molecular and cellular levels in the distant future ( 20 – 22 ). Finally, our study is available via a web service ( ).…”

Discovering Haematoma-Stimulated Circuits for Secondary Brain Injury after Intraventricular Haemorrhage by Spatial Transcriptome Analysis

“…In summary, our study not only identified the brain regions affected by secondary neurological dysfunction after IVH 15–17 from a 3D perspective but it also has the potential for us to construct corresponding intervention strategies for acute traumatic brain trauma at the molecular and cellular levels in the distant future.…”