2021
DOI: 10.1021/acssensors.1c00972
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Development of an Electrochemical CCL17/TARC Biosensor toward Rapid Triage and Monitoring of Classic Hodgkin Lymphoma

Abstract: A point-of-care blood test for the detection of an emerging biomarker, CCL17/TARC, could prove transformative for the clinical management of classic Hodgkin lymphoma (cHL). Primary care diagnosis is challenging due to nonspecific clinical presentation and lack of a diagnostic test, leading to significant diagnostic delays. Treatment monitoring encounters false-positive and negative results, leading to avoidable chemotherapy toxicity, or undertreatment, impacting patient morbidity and mortality. Here, we presen… Show more

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Cited by 7 publications
(6 citation statements)
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“…In this regard, serum CD163 and serum thymus and activation-regulated chemokine (TARC) are proposed as striking biomarkers reflecting therapy response in patients with HL [ 71 ]. CCL17/TARC is another biomarker with the potential to facilitate primary care triage and chemotherapy monitoring strategies for classic Hodgkin lymphoma (cHL) [ 72 ]. Determining the levels of a combination of biomarkers such as Nuclear Factor Kappa B (NF-κB) and CD30 in pediatric HL patients would support gaining insight into disease progression during tumor treatment [ 56 ].…”
Section: Potential Biomarkers For Childhood Cancersmentioning
confidence: 99%
See 2 more Smart Citations
“…In this regard, serum CD163 and serum thymus and activation-regulated chemokine (TARC) are proposed as striking biomarkers reflecting therapy response in patients with HL [ 71 ]. CCL17/TARC is another biomarker with the potential to facilitate primary care triage and chemotherapy monitoring strategies for classic Hodgkin lymphoma (cHL) [ 72 ]. Determining the levels of a combination of biomarkers such as Nuclear Factor Kappa B (NF-κB) and CD30 in pediatric HL patients would support gaining insight into disease progression during tumor treatment [ 56 ].…”
Section: Potential Biomarkers For Childhood Cancersmentioning
confidence: 99%
“…Recently, Rinaldi et al [ 72 ] presented an electrochemical sandwich immunosensor as a point-of-care test for CCL17/TARC detection as a potential biomarker of cHL ( Figure 3 ). The proposed sensor was able to distinguish patients with cHL from healthy volunteers as well as perform secondary care chemotherapy monitoring.…”
Section: Developed Biosensors For Childhood Cancers In Clinical Practicementioning
confidence: 99%
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“…The chronoamperometric detection method can be used in combination with immunosandwich complexes to render the electrochemical signal dependent on an antigen concentration, as demonstrated in [29,[48][49][50][51]. A standard practice for biosensors is to amplify the signal as a means of increasing the sensitivity.…”
Section: Electrochemical Signal Amplification Strategymentioning
confidence: 99%
“…Sometimes, the nanomaterials are not even incorporated into the sensor development but to obtain a low detection limit, nanomaterials are incorporated in the sensor fabrication processes. Electrochemical approaches have provided novel opportunities for the detection of biological molecules [21][22][23][24], illegal substances, heavy metals [20,25], and organic pollutants [26,27]. This method can also take advantage of smart nanomaterials, which allow for quicker electron transit, better conductivity, and quantum effects to improve sensitivity and selectivity within complicated matrices [28,29].…”
Section: Introductionmentioning
confidence: 99%