Development of an enzyme-linked immunosorbent assay for fentanyl and applications of fentanyl antibody-coated nanoparticles for sample preparation

Mao, Chi-Liang; Zientek, Keith; Colahan, Patrick T.; Kuo, Mei-Yueh; Liu, Chi-Ho; Lee, Kuo-Ming; Chou, Chi‐Chung

doi:10.1016/j.jpba.2006.03.009

Cited by 18 publications

(16 citation statements)

References 34 publications

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“…These methods have served to improve the detection limits of earlier techniques and have even been proposed as rapid screening methods [92,[145][146][147][148][149][150][151]. Tumorigenic polynuclear aromatic hydrocarbons such as ergosterol, sulfonamides or salicylic acid have been isolated by magnetic solid-phase extraction.…”

Section: Organic Compoundsmentioning

confidence: 99%

Magnetic solids in analytical chemistry: A review

Aguilar-Arteaga

Rodríguez

Barrado

2010

Analytica Chimica Acta

397

148

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Section: Organic Compoundsmentioning

confidence: 99%

Magnetic solids in analytical chemistry: A review

Aguilar-Arteaga

Rodríguez

Barrado

2010

Analytica Chimica Acta

397

148

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“…Since fentanyl is an important prescription opioid with documented abuse potential, detection of this drug in urine screening is highly desirable. Although not routinely applied in many standard urine drug-testing panels, fentanyl-specific immunoassays have been developed [27,61,62]. A number of other analytical methods including gas chromatography-mass spectroscopy (GC-MS) [63][64][65][66] and LC-MS have also been described [67][68][69][70].…”

Section: Fentanylmentioning

confidence: 99%

Laboratory Testing for Prescription Opioids

Milone

2012

J. Med. Toxicol.

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Opioid analgesic misuse has risen significantly over the past two decades, and these drugs now represent the most commonly abused class of prescription medications. They are a major cause of poisoning deaths in the USA exceeding heroin and cocaine. Laboratory testing plays a role in the detection of opioid misuse and the evaluation of patients with opioid intoxication. Laboratories use both immunoassay and chromatographic methods (e.g., liquid chromatography with mass spectrometry detection), often in combination, to yield high detection sensitivity and drug specificity. Testing methods for opioids originated in the workplace-testing arena and focused on detection of illicit heroin use. Analysis for a wide range of opioids is now required in the context of the prescription opioid epidemic. Testing methods have also been primarily based upon urine screening; however, methods for analyzing alternative samples such as saliva, sweat, and hair are available. Application of testing to monitor prescription opioid drug therapy is an increasingly important use of drug testing, and this area of testing introduces new interpretative challenges. In particular, drug metabolism may transform one clinically available opioid into another. The sensitivity of testing methods also varies considerably across the spectrum of opioid drugs. An understanding of opioid metabolism and method sensitivity towards different opioid drugs is therefore essential to effective use of these tests. Improved testing algorithms and more research into the effective use of drug testing in the clinical setting, particularly in pain medicine and substance abuse, are needed.

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“…15. The number of lines of code to specify Image Probe Synthesis, Glucose Detection, Neurotransmitter Sensing, PCR [Amin et al 2007], Probabilistic PCR [Luo et al 2015], PCR w/ Droplet Replacement [Jebrail et al 2015], and Opiate Detection [Backer et al 2005;Jiang et al 2011;Mao et al 2006] in AIS [Amin et al 2007], BioCoder [Ananthanarayanan and Thies 2010;Curtis and Brisk 2015;, Antha [Synthace 2016], and BioScript. We were unable to specify the latter three assays in AIS and Antha.…”

Section: Discussionmentioning

confidence: 99%

BioScript: programming safe chemistry on laboratories-on-a-chip

Ott

Loveless

Curtis

et al. 2018

Proc. ACM Program. Lang.

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This paper introduces BioScript, a domain-specific language (DSL) for programmable biochemistry which executes on emerging microfluidic platforms. The goal of this research is to provide a simple, intuitive, and type-safe DSL that is accessible to life science practitioners. The novel feature of the language is its syntax, which aims to optimize human readability; the technical contributions of the paper include the BioScript type system and relevant portions of its compiler. The type system ensures that certain types of errors, specific to biochemistry, do not occur, including the interaction of chemicals that may be unsafe. The compiler includes novel optimizations that place biochemical operations to execute concurrently on a spatial 2D array platform on the granularity of a control flow graph, as opposed to individual basic blocks. Results are obtained using both a cycle-accurate microfluidic simulator and a software interface to a real-world platform. CCS Concepts: • Software and its engineering → Domain specific languages; General programming languages; • Theory of computation → Logic; Type theory; • Social and professional topics → History of programming languages;

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Development of an enzyme-linked immunosorbent assay for fentanyl and applications of fentanyl antibody-coated nanoparticles for sample preparation

Cited by 18 publications

References 34 publications

Magnetic solids in analytical chemistry: A review

Magnetic solids in analytical chemistry: A review

Laboratory Testing for Prescription Opioids

BioScript: programming safe chemistry on laboratories-on-a-chip

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