Development of an Experimental Model of Portal Vein Ligation Associated With Parenchymal Transection (ALPPS) in Rats

Trenard, Héctor M. Almau; Moulin, L.; Padín, Juan Manuel; Stringa, Pablo; Gondolesi, Gabriel; Schelotto, Pablo Barros

doi:10.1016/j.cireng.2013.11.019

Cited by 17 publications

(8 citation statements)

References 16 publications

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“…Liver regeneration was assessed by volume increase percentage of the RML at day 7 after surgery according to the following formula:

Volume increase percentage (VI %) = ({normalV}_{post} - {normalV}_{pre}) / {normalV}_{pre} \times 100 %

. The ratio of the RML volume (V FLR ) to total liver volume (V total liver ) after surgery was also calculated:

{FLR % = (V}_{FLR} {/ V}_{total liver}) \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

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Histogram analyses of diffusion kurtosis indices and apparent diffusion coefficient in assessing liver regeneration after ALPPS and a comparative study with portal vein ligation

Sheng

Wang

Jin

et al. 2017

Magnetic Resonance Imaging

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“…Liver regeneration was assessed by volume increase percentage of the RML at day 7 after surgery according to the following formula:

Volume increase percentage (VI %) = ({normalV}_{post} - {normalV}_{pre}) / {normalV}_{pre} \times 100 %

. The ratio of the RML volume (V FLR ) to total liver volume (V total liver ) after surgery was also calculated:

{FLR % = (V}_{FLR} {/ V}_{total liver}) \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

“…All statistical analyses were performed using SPSS v. 22.0 (Chicago, IL). Mean volumes of the RML before and after ALPPS were compared using a paired t-test, volume increase percentages of the RML and ratios of RML to total liver volume between ALPPS and PVL groups were compared using an unpaired t-test.…”

Section: Statistical Analysesmentioning

confidence: 99%

Histogram analyses of diffusion kurtosis indices and apparent diffusion coefficient in assessing liver regeneration after ALPPS and a comparative study with portal vein ligation

Sheng

Wang

Jin

et al. 2017

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Liver regeneration was assessed by the volume increase percentage of the RML at day 7 after surgery according to the following formula: Volume increase percentage (VI%) = (V post − V pre )/V pre × 100%. 21 The ratio of the RML volume (V FLR ) to the total liver volume (V total liver ) after surgery was determined using the following formula: FLR% = (V FLR /V total liver ) × 100%. 2,5 Pathological analysis After MR examination, the rats were humanely sacrificed.…”

Section: Mr Liver Volumetrymentioning

confidence: 99%

Assessment of liver regeneration after associating liver partition and portal vein ligation for staged hepatectomy: a comparative study with portal vein ligation

Sheng

Yang

Jin

et al. 2018

HPB

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“…This is in contrast to our 17 and similar rat models. 14,21,22,23 The advantage of a murine model may be the use of genetically modified animals. Alternatively to these small animal models, a pig model has been developed, 16 using a similar surgical technique as in humans and resulting in similar growth rates.…”

Section: Discussionmentioning

confidence: 99%

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Schadde

Hertl

Breitenstein

et al. 2017

JoVE

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Recent clinical data support an aggressive surgical approach to both primary and metastatic liver tumors. For some indications, like colorectal liver metastases, the amount of liver tissue left behind after liver resection has become the main limiting factor of resectability of large or multiple liver tumors. A minimal amount of functional tissue is required to avoid the severe complication of post-hepatectomy liver failure, which has high morbidity and mortality. Inducing liver growth of the prospective remnant prior to resection has become more established in liver surgery, either in the form of portal vein embolization by interventional radiologists or in the form of portal vein ligation several weeks prior to resection. Recently, it was shown that liver regeneration is more extensive and rapid, when the parenchymal transection is added to portal vein ligation in a first stage and then, after only one week of waiting, resection performed in a second stage (Associating Liver Partition and Portal vein ligation for Staged hepatectomy = ALPPS). ALPPS has rapidly become popular across the world, but has been criticized for its high perioperative mortality. The mechanism of accelerated and extensive growth induced by this procedure has not been well understood. Animal models have been developed to explore both the physiological and molecular mechanisms of accelerated liver regeneration in ALPPS. This protocol presents a rat model that allows mechanistic exploration of accelerated regeneration.

show abstract

Development of an Experimental Model of Portal Vein Ligation Associated With Parenchymal Transection (ALPPS) in Rats

Cited by 17 publications

References 16 publications

Histogram analyses of diffusion kurtosis indices and apparent diffusion coefficient in assessing liver regeneration after ALPPS and a comparative study with portal vein ligation

Histogram analyses of diffusion kurtosis indices and apparent diffusion coefficient in assessing liver regeneration after ALPPS and a comparative study with portal vein ligation

Assessment of liver regeneration after associating liver partition and portal vein ligation for staged hepatectomy: a comparative study with portal vein ligation

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

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