2024
DOI: 10.1101/2024.02.08.579322
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

Barnabas G. Williams,
Lloyd D. W. King,
David Pulido
et al.

Abstract: In recent years, reticulocyte-binding protein homologue 5 (RH5) has emerged as a leading blood-stage Plasmodium falciparum malaria vaccine antigen. The most advanced blood-stage vaccine candidate in a Phase 2b clinical trial, RH5.1/Matrix-M[TM], is based on a full-length soluble protein-with-adjuvant formulation. RH5 interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeric RCR-complex. Here, we investigated whether a vaccine candidate based … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 63 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?