Development of an inactivated combined vaccine for protection of cattle against lumpy skin disease and bluetongue viruses

Es-Sadeqy, Y.; Bamouh, Zahra; Ennahli, Abderrahim; Safini, Najete; Mejdoub, Soufiane El; Tadlaoui, Khalid Omari; Gavrilov, Boris; Harrak, Mehdi El

doi:10.1016/j.vetmic.2021.109046

Cited by 14 publications

(8 citation statements)

References 34 publications

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“…They have been used in sheep to protect them against SPPV [ 67 , 68 , 69 ]. In contrast, it is only recently that their potential against LSDV has surfaced [ 22 , 23 , 70 ]. The inactivated vaccine used in this study was well-tolerated by the animals, as almost no side-effects were seen and were lesser than those of the live attenuated vaccine.…”

Section: Discussionmentioning

confidence: 99%

Duration of Immunity Induced after Vaccination of Cattle with a Live Attenuated or Inactivated Lumpy Skin Disease Virus Vaccine

et al. 2023

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Vaccines have proven themselves as an efficient way to control and eradicate lumpy skin disease (LSD). In addition to the safety and efficacy aspects, it is important to know the duration for which the vaccines confer protective immunity, as this impacts the design of an efficient control and eradication program. We evaluated the duration of immunity induced by a live attenuated vaccine (LSDV LAV) and an inactivated vaccine (LSDV Inac), both based on LSDV. Cattle were vaccinated and challenged after 6, 12 and 18 months for LSDV LAV or after 6 and 12 months for the LSDV Inac. The LSDV LAV elicited a strong immune response and protection for up to 18 months, as no clinical signs or viremia could be observed after a viral LSDV challenge in any of the vaccinated animals. A good immune response and protection were similarly seen for the LSDV Inac after 6 months. However, two animals developed clinical signs and viremia when challenged after 12 months. In conclusion, our data support the annual booster vaccination when using the live attenuated vaccine, as recommended by the manufacturer, which could potentially even be prolonged. In contrast, a bi-annual vaccination seems necessary when using the inactivated vaccine.

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Section: Discussionmentioning

confidence: 99%

Duration of Immunity Induced after Vaccination of Cattle with a Live Attenuated or Inactivated Lumpy Skin Disease Virus Vaccine

et al. 2023

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“…As a result, developments have been made to produce safer LSDV vaccines and to further improve their immunogenicity. Chemically inactivated nLSDV vaccines with adjuvants have been developed as safer alternatives to live nLSDV [ 85 , 86 , 88 , 89 , 90 ]. The combination of a low-molecular-weight copolymer adjuvant and inactivated LSDV, at titres similar to live vaccines, has given protection from LSDV challenge [ 85 ].…”

Section: Introductionmentioning

confidence: 99%

Lumpy Skin Disease—An Emerging Cattle Disease in Europe and Asia

2023

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Lumpy skin disease virus (LSDV) is a member of the Capripoxvirus genus, mainly infecting cattle and buffalo, which until relatively recently was only endemic in parts of Africa and then spread to the Middle East and lately Europe and Asia. Lumpy skin disease (LSD) is a notifiable disease with a serious impact on the beef industry as it causes mortality of up to 10% and has impacts on milk and meat production, as well as fertility. The close serological relationship between LSDV, goat poxvirus (GTPV) and sheep poxvirus (SPPV) has led to live attenuated GTPV and SPPV vaccines being used to protect against LSD in some countries. There is evidence that the SPPV vaccine does not protect from LSD as well as the GTPV and LSDV vaccines. One of the LSD vaccines used in Eastern Europe was found to be a combination of different Capripoxviruses, and a series of recombination events in the manufacturing process resulted in cattle being vaccinated with a range of recombinant LSDVs resulting in virulent LSDV which spread throughout Asia. It is likely that LSD will become endemic throughout Asia as it will be very challenging to control the spread of the virus without widespread vaccination.

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“…Interestingly, in this particular scenario, the inactivated vaccines induced a higher antibody response (87%) in comparison with the live-attenuated jabs (50%), at 28 days postvaccination (Hamdi et al, 2020). Another bivalent inactivated vaccine conjugated with oil adjuvants against the LSDV and bluetongue virus was reported recently, which could stimulate the production of neutralizing antibodies at high titers (Es-sadeqy et al, 2021). Moreover, recombinant LSD vaccines, namely, LSDV-WB005KO and LSDV-WB008KO, have also been developed using a homologous recombination technique by deleting the LSDV open reading frames 005 and 008 (Liang et al, 2022).…”

Section: Diagnosis Preventive Measures and Treatment Of Lsdmentioning

confidence: 86%

Lumpy Skin Disease: A Comprehensive Review on Virus Biology, Pathogenesis, and Sudden Global Emergence

Moudgil¹,

Chadha²,

Khullar³

et al. 2023

Preprint

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The lumpy skin disease virus (LSDV) is an animal virus and a member of the Poxviridae family, which causes lumpy skin disease (LSD) in livestock animals like cows and buffaloes. LSD is an important transboundary disease of economic importance that was first discovered in 1929 in Zambia. LSDV has been prevalent in African countries, where several outbreaks have been reported previously. However, the virus has spread rapidly across the Middle East in the past two decades, reaching Russia and, recently, the Asian subcontinent. With the unprecedented cluster outbreaks reported across Asian countries, LSDV is certainly undergoing an epidemiological shift and expanding its geographical footprint globally. The recent LSD outbreaks have gained attention from global regulatory authorities and raised serious concerns among epidemiologists and veterinary researchers. Although there is no dearth of knowledge about LSDV, the disease lacks networked global surveillance and management, consequently making the current statistics deficient, fragmented, and unreliable. Hence, recurrent LSD outbreaks seriously threaten the global livestock industry. This review provides recent insights into LSDV by augmenting latest literature associated with its epidemiology, pathogenesis, transmission, currently-available intervention strategies, and economic implications on the dairy industries. The review also critically examines the changing epidemiological footprint of LSD and speculates on the possible reasons contributing to the ongoing multi-country LSD outbreak.

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Development of an inactivated combined vaccine for protection of cattle against lumpy skin disease and bluetongue viruses

Cited by 14 publications

References 34 publications

Duration of Immunity Induced after Vaccination of Cattle with a Live Attenuated or Inactivated Lumpy Skin Disease Virus Vaccine

Duration of Immunity Induced after Vaccination of Cattle with a Live Attenuated or Inactivated Lumpy Skin Disease Virus Vaccine

Lumpy Skin Disease—An Emerging Cattle Disease in Europe and Asia

Lumpy Skin Disease: A Comprehensive Review on Virus Biology, Pathogenesis, and Sudden Global Emergence

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