The present study is to develop a Nurse-Centered Doula Support Program (NDSP) for the management of pain and childbirth support in natural births and to evaluate its effect. Methods: Sixty items were derived by 5 experts and the final contents of program were confirmed with the verification of 58 items with content validity index of 0.8 or more, by an expert group consisting of 2 obstetricians and 3 maternity nurses. Twenty-four pregnant women admitted for maternity care at Mediflower hos pital in Seoul were included in the evaluation of NDSP efficacy. Pain, anxiety, postpartum hemorrhage, type of birth, and the birth satisfaction of the newborn were assessed for the evaluation. Results: This study showed that compared to non-NDSP-applied group, NDSP-applied group had lower pain scores during transitional phase and lower postpartum anxiety score. Also, postpartum hemorrhage was less frequently found in NDSP-applied group, with higher birth satisfaction, when compared to the non-NDSP-applied group. Conclusion: These results suggest that the NDSP developed by the present researcher is effective in reducing maternal pain, anxiety, postpartum hemorrhage, and birth satisfaction in natural births, and thereby, is expected to be used as nursing intervention in maternal care.