Development of an Optimised Losartan Potassium Press-Coated Tablets for Chronotherapeutic Drug Delivery

K, Latha; Uhumwangho, MU; Sunil, SA; Mv, Srikanth; Murthy, K. V. R.

doi:10.4314/tjpr.v10i5.3

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…Latha et al were developed optimized Losartan Potassium Press-coated Tablets for pulsatile release of Drug. The inner core of the tablet was prepared by compression-coating with HPMC 100 KM along and admixed with MCC as the outer layer in different ratios with the lag-time was from 0.5 to 18.5 hrs [16].…”

Section: Results Obtained Formentioning

confidence: 99%

Pulsatile Drug Delivery System (PDDS): A Cronotherapeutic Approach for Optimum Therapy

Dash

Sahoo

Padhan

et al. 2022

JPRI

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Now a day’s PDDS are gaining more attraction and importance especially for the disease follow circadian rhythms. Some chronic disease like rheumatoid arthritis, asthma, hypercholesterolemia, hyper acidity and cardio vascular diseases where peak symptoms tends to follow a 24 hour cycle called circadian rhythms. Optimum therapy of these diseases demands a drug delivery system where Cmax of the drug achieve exactly at the time of peak of the disease. This is only possible by chronotherapeutic approach i.e. pulsatile drug delivery system. This delivery system not only releases the right amount of drug at the right time but also overcome the other challenges like drug tolerance and over dose associated with traditional sustained or extended release drug delivery system. Drugs under goes extensive first pass metabolism, degradation in gastric acid medium, having biological tolerance and targeted to distal parts of GIT are suitable candidates for PDDS. It has many advantages like pre-programmed delayed-release, multiple dosing option, reduce drug loss, less drug interaction and improve patient compliance etc There are various technologies of PDDS like C O D A S ® ,O R O S ® , DIFFUCAPS ®,3D Printing, PULSINCAPTM are already available in the market. The current work is focused on the requirements, advantages, disadvantages and a review on various drugs and polymers used to develop PDDS in current & past decades. The study revealed that, PDDS has a tremendous scope and can play a vital role in the optimum treatment of many chronic diseases which follows circadian rhythm.

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Section: Results Obtained Formentioning

confidence: 99%

Pulsatile Drug Delivery System (PDDS): A Cronotherapeutic Approach for Optimum Therapy

Dash

Sahoo

Padhan

et al. 2022

JPRI

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show abstract

“…Latha had optimized Losartan Potassium Press-Coated Tablets for pulsatile drug release. The inner core of the tablet was created by compressioncoating HPMC 100 KM coupled with microcrystalline cellulose as the exterior layer in various ratios with lag times ranging from 0.5 to 18.5 h [33]. Jagdale have developed an enteric-press-coated atenolol tablet for pulsatile method of drug delivery.…”

Section: The Cardiovascular Systemmentioning

confidence: 99%

Pulsatile Drug Delivery: A Strategy for Treating Chronotherapeutic Ailments

J.,

B.,

M. F.

2023

Int J Curr Pharm Sci

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Modern drug delivery systems have been promoted to a unique notion of chronopharmacology, i.e., the ability to provide the medicament to a patient in a staggered profile, as the discipline of chronobiology has advanced. The main disadvantage of developing such a delivery system that fits the circadian cycle is the lack of accurate technology (Pulsatile drug delivery system, PDDS). Pulsatile devices are gaining popularity because they deliver the medicine to the correct region of action at the correct time, allowing for spatial and temporal dosing and compliance among patients. These technologies are meant to work with the body's natural circadian cycle. The circadian rhythm affects various biological systems in humans, including metabolism, physiology, behaviour, sleep patterns, hormone synthesis, and so on. This article addresses several methods, such as osmotic systems, capsular systems, single and multiple-unit programable devices that rely on soluble or erodible polymer coatings, and the usage of rupturable membranes. The present review covered the rationale for the creation of pulsatile drug delivery systems, benefits, limitations the types of diseases that require pulsatile release, categorization, and assessments of pulsatile system of drug delivery.

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“…Avicel 102 enhances water diffusion into the gel by wicking mechanism; it imparts its disintegrating action through porosity and capillary action. Avicel particles themselves act as pore-forming agents providing pathways for liquids to the tablets (Latha et al, 2011). PEG 6000 was used as a channeling agent since it is soluble and tends to leach from formulation leaving tortuous capillaries in tablets (Balaji, Umashankar, Kavitha, 2014).…”

Section: Post Compression Evaluation Of Eplerenone Presscoated Tabletsmentioning

confidence: 99%

Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

Marzouk

Darwish

Yassin

et al. 2022

Braz. J. Pharm. Sci.

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Development of an Optimised Losartan Potassium Press-Coated Tablets for Chronotherapeutic Drug Delivery

Cited by 9 publications

References 12 publications

Pulsatile Drug Delivery System (PDDS): A Cronotherapeutic Approach for Optimum Therapy

Pulsatile Drug Delivery System (PDDS): A Cronotherapeutic Approach for Optimum Therapy

Pulsatile Drug Delivery: A Strategy for Treating Chronotherapeutic Ailments

Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

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