Development of an Orthotopic Pulmonary Valve Replacement Porcine Model for Mechanical Heart Valve Thrombosis Research
Tom Langenaeken,
Pieter De Meester,
Manon Van Hecke
et al.
Abstract:Objective
Animal models play a vital role in preclinical cardiovascular testing of materials. While sheep have traditionally served as the standard for preclinical cardiovascular testing, pigs are considered a superior option due to a more comparable coagulation system. This study aimed to compare the thrombogenicity of sheep and pigs in a pulmonary valve replacement model.
Methods
Pigs (n = 12) and sheep (n = 5) underwent pulmonary valve replacement using a bileaflet mechanical valve without any antithromb… Show more
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