Development of an RNA virus-based episomal vector with artificial aptazyme for gene silencing
Ryo Komorizono,
Shima Yoshizumi,
Keizo Tomonaga
Abstract:RNA virus-based episomal vector (REVec), engineered from Borna disease virus, is an innovative gene delivery tool that enables sustained gene expression in transduced cells. However, the difficulty in controlling gene expression and eliminating vectors has limited the practical use of REVec. In this study, we overcome these shortcomings by inserting artificial aptazymes into the untranslated regions of foreign genes carried in vectors or downstream of the viral phosphoprotein gene, which is essential for vecto… Show more
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