Development of anti-filarial antibodies in a group of expatriate mine-site workers with varying exposure to the disease

Melrose, Wayne; Usurup, J. P.; Selve, Billy; Pisters, Peter W.T.; Turner, Peter

doi:10.1016/s0035-9203(00)90242-6

Cited by 6 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A screening antifilarial ELISA was undertaken as described previously. 7 The antigen used was a commercial preparation of adult dog heartworm (D. immitis) (Agen, Brisbane, Queensland, Australia). A pool of 100 sera obtained from Papua New Guinean subjects infected with W. bancrofti was used on each test plate in serial dilution as a positive control.…”

Section: Methodsmentioning

confidence: 99%

“…5 In contrast, no lymphatic filariasis was detected among 4,575 US Special Forces soldiers living in 28 camps in South Vietnam. 6 Lymphatic filariasis has also been observed among missionaries, expatriates working in endemic areas and travelers, 7 and among transmigrants in Indonesia. 8 In people from nonendemic areas infection is characterized by a brisk immune response and a good prognosis, even untreated, as long as exposure ceases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroconversion to Filarial Antigens in Australian Defence Force Personnel in Timor-Leste

Frances¹,

Baade²,

Kubofcik³

et al. 2008

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

To investigate whether Australian soldiers were exposed to filarial parasites that cause lymphatic filariasis during a 6-month deployment to Timor-Leste, antifilarial antibody levels were measured in 907 soldiers using an enzyme linked immunosorbent assay (ELISA). Initial testing using Dirofilaria immitis antigen demonstrated that 49 of 907 (5.4%) soldiers developed antifilarial antibodies of the IgG1 subclass after deployment, whereas 1 of 944 (0.1%) seroconverted to the IgG4 subclass. When a sub sample of 88 D. immitis-reactive sera was subject to testing with an antifilarial antibody test using Brugia malayi antigen, 46 had elevated IgG antibodies, whereas 5 had elevated antibodies of the IgG4 subclass. A total of 24 soldiers seroconverted to B. malayi, as measured by parasite-specific IgG, whereas 1 seroconverted to IgG4. The relatively low number of seroconversions indicates a low but measurable risk of exposure to human filarial parasites among Australian soldiers deployed to Timor-Leste. However, to reduce the risk of exposure to these parasites, soldiers deploying to endemic areas should practice strict adherence to personal protective measures against mosquito bites.

show abstract

Section: Methodsmentioning

confidence: 99%