Development of antimicrobial and scar preventive chitosan hydrogel wound dressings

Anjum, Sadiya; Arora, Abha; Alam, Mohammad Sarwar; Gupta, Bhuvanesh

doi:10.1016/j.ijpharm.2016.05.013

Cited by 185 publications

(90 citation statements)

References 27 publications

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“…found that chitosan/agarose hydrogels could kill bacteria and repair the damaged skin with less scar formation. This finding was consistent with the study conducted by Anjum et al . that the hydrogels made of chitosan, poly(ethylene glycol) and polyvinylpyrrolidone could work as antimicrobial and scar preventive dressings.…”

Section: Multiple Applicationssupporting

confidence: 93%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Multiple Applicationssupporting

confidence: 93%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…Marcol et al studied microcrystallic chitosan gel repair of rat sciatic nerves and found significant reductions in both neuroma and scar formation compared to control animals without the biopolymer repair. When used as a component of wound dressing, chitosan promoted favorable epithelialization with limited scar . The biopolymer can be constructed to be highly porous, allowing for gas and nutrient exchange .…”

Section: Discussionmentioning

confidence: 99%

Nerve transection repair using laser‐activated chitosan in a rat model

et al. 2017

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“…However, given that Ag ions have been proven to be highly toxic, wound healing is often delayed. Thus, modified chitosan or chitosan derivatives and new alginate‐based antibacterial hydrogels dressings have attracted increased research attention …”

Section: Methodsmentioning

confidence: 99%

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

et al. 2020

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Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. In this work, trithiophene aldehyde (3T‐CHO) as a new photosensitizers was isolated from Herba Ecliptae, and tryptophan (Trp) modified 3T‐CHO improve water solubility and reduced phototoxicity. The photosensitizer‐loaded vesicles were incorporated into a gel scaffold to obtain a wound dressing with detection and antibacterial function. Detection of the presence of pathogenic bacteria, such as Pseudomonas aeruginosa, based on the fluorescence signals was highly efficient and sensitive. The cytotoxin produced by the pathogenic bacteria to induce vesicle lysis, thereby the photosensitive antibacterial agent was released from the vesicle to realize the simultaneous intelligent detection and treatment of pathogenic bacteria. Compared with traditional dressings coated with antibiotics, the synthesized dressing avoids the drawback of pathogenic bacteria developing drug resistance. The proposed microbiologically responsive wound dressing could be used as a general methodology for the design and fabrication of bacterium‐responsive functional biomaterials.

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Development of antimicrobial and scar preventive chitosan hydrogel wound dressings

Cited by 185 publications

References 27 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Nerve transection repair using laser‐activated chitosan in a rat model

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

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