Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

Ali, Samer Hussein Al; Zainal, Zulkarnain; Hakim, Muhammad Nazrul; Hussein, Mohd Zobir

doi:10.2147/ijn.s21567

Cited by 82 publications

(25 citation statements)

References 54 publications

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“…At pH 4.8, the correlation coefficient (R 2 ) and k 2 values are 0.9999 and 1.0 × 10 -4 mg/min, respectively and at pH 7.4, the corresponding value is 0.9982 and 3.9 × 10 -5 mg/min, respectively. The release kinetic results are similar to the hippurate-zinc layered hydroxide, ellagic acid-zinc layered hydroxide and citirizine-zinc layered hydroxide synthesized by the direct reaction of zinc oxide with drugs [14,15,33] (Table 3). …”

Section: Resultssupporting

confidence: 66%

“…The solution was kept on stirring for 18 hours at 70°C. The sample was centrifuged and washed with deionized water and kept in an oven at 70°C for 48 hours and the sample was then subjected to further characterizations [14,17,18]. …”

Section: Methodsmentioning

confidence: 99%

“…In previous studies it has been reported, that the Zn-Al LDH does not show any toxic effect on Chinese hamster ovary cells at low concentration [13]. ZLH has also been used as a drug delivery system of an anticancer compound, ellagic acid [14]. The intercalation of hippuric acid into ZLH has resulted in the less toxic of the compound compared to the pure hippuric acid itself [15].…”

Section: Introductionmentioning

confidence: 99%

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Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Saifullah

Hussein

Hussein‐Al‐Ali

et al. 2013

Chemistry Central Journal

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BackgroundTuberculosis (TB), is caused by the bacteria, Mycobacterium tuberculosis and its a threat to humans since centuries. Depending on the type of TB, its treatment can last for 6–24 months which is a major cause for patients non-compliance and treatment failure. Many adverse effects are associated with the currently available TB medicines, and there has been no new anti-tuberculosis drug on the market for more than 50 year, as the drug development is very lengthy and budget consuming process.Development of the biocompatible nano drug delivery systems with the ability to minimize the side effects of the drugs, protection of the drug from enzymatic degradation. And most importantly the drug delivery systems which can deliver the drug at target site would increase the therapeutic efficacy. Nanovehicles with their tendency to release the drug in a sustained manner would result in the bioavalibilty of the drugs in the body for a longer period of time and this would reduce the dosing frequency in drug administration. The biocompatible nanovehicles with the properties like sustained release of drug of the target site, protection of the drug from physio-chemical degradation, reduction in dosing frequency, and prolong bioavailability of drug in the body would result in the shortening of the treatment duration. All of these factors would improve the patient compliance with chemotherapy of TB.ResultAn anti-tuberculosis drug, 4-amino salicylic acid (4-ASA) was successfully intercalated into the interlamellae of zinc layered hydroxide (ZLH) via direct reaction with zinc oxide suspension. The X-ray diffraction patterns and FTIR analyses indicate that the molecule was successfully intercalated into the ZLH interlayer space with an average basal spacing of 24 Å. Furthermore, TGA and DTG results show that the drug 4-ASA is stabilized in the interlayers by electrostatic interaction. The release of 4-ASA from the nanocomposite was found to be in a sustained manner. The nanocomposite treated with normal 3T3 cells shows it reduces cell viability in a dose- and time-dependent manner.ConclusionsSustained release formulation of the nanocomposite, 4-ASA intercalated into zinc layered hydroxides, with its ease of preparation, sustained release of the active and less-toxic to the cell is a step forward for a more patient-friendly chemotherapy of Tuberculosis.

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Section: Resultssupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Saifullah

Hussein

Hussein‐Al‐Ali

et al. 2013

Chemistry Central Journal

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“…A wide variety of guest molecules has been intercalated into the interlayer region of LHS, mainly via ion exchange process, ranging from anionic dyes [14], porphyrin sensitizers [15] and an anti corrosive compound [16]. In particular, LHS has demonstrated the ability to extend the release period of bioactive molecules [17] and drug molecules [18], prompting more investigations towards potential applications of LHS in drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Latip

Hussein

Stanslas

et al. 2013

Chemistry Central Journal

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BackgroundLayered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxacin (CFX), a broad spectrum antibiotic via ion exchange in a mixture solution of water:ethanol.ResultsPowder x-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the drug anions were successfully intercalated in the interlayer space of LZH. Specific surface area of the obtained compound was increased compared to that of the host due to the different pore textures between the two materials. CFX anions were slowly released over 80 hours in phosphate-buffered saline (PBS) solution due to strong interactions that occurred between the intercalated anions and the host lattices. The intercalation compound demonstrated enhanced antiproliferative effects towards A549 cancer cells compared to the toxicity of CFX alone.ConclusionsStrong host-guest interactions between the LZH lattice and the CFX anion give rise to a new intercalation compound that demonstrates sustained release mode and enhanced toxicity effects towards A549 cell lines. These findings should serve as foundations towards further developments of the brucite-like host material in drug delivery systems.

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“…The hippuric acid nanocomposite (HAN) was synthesized by the direct method using ZnO as the starting material as reported previously,9,13,14 with minor modifications. The hippuric acid solution (0.01 Mole) was prepared using 1.8 g of hippuric acid in 20 mL of DMSO, and was adjusted to 50 mL by the addition of deionized water.…”

Section: Methodsmentioning

confidence: 99%

Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines

Ali¹,

Al‐Qubaisi²,

Hussein³

et al. 2013

DDDT

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BackgroundThe aim of the current study is to design a new nanocomposite for inducing cytotoxicity of doxorubicin and oxaliplatin toward MDA-MB231, MCF-7, and Caco2 cell lines. A hippuric acid (HA) zinc layered hydroxide (ZLH) nanocomposite was synthesized under an aqueous environment using HA and zinc oxide (ZnO) as the precursors.MethodsThe hippuric acid nanocomposite (HAN) was prepared by the direct reaction of a HA solution with an aqueous suspension of ZnO.ResultsThe basal spacing of the nanocomposite was 21.3 Å, which is average of four harmonics at 2θ = 8.32°, 12.50°, 16.68°, and 20.84°. This result indicates that the hippurate anion was successfully intercalated into the interlayer space of ZLH. The combinations of HAN with chemotherapy (drugs) has inhibited the cell growth of the MDA-MB231, MCF-7, and Caco2 cancer cells when compared to drugs alone. An IC50 value for the combination of HAN with doxorubicin toward MCF-7 is 0.19 ± 0.15 μg/mL and toward MDA-MB231 is 0.13 ± 0.10 μg/mL. Similarly, the IC50 for the combination of HAN with oxaliplatin toward Caco2 is 0.24 ± 0.11 μg/mL. In the antiproliferative results, the equal combination of HAN (0.5 μg/mL) with doxorubicin (0.5 μg/mL) has reduced the cell proliferation in MCF-7 and MDA-MB-231 cells into 37.3% and 17.6%, respectively after 24 hours. Similarly, the antiproliferation percentage for equal combination HAN with oxaliplatin (5.00 μg/mL) toward Caco2 is 72.7% after 24 hours.ConclusionThe resulting combination HAN with drugs has exhibited higher inhibition in cells growth in all cancer cell lines.

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Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

Cited by 82 publications

References 54 publications

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite

Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines

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