Development of apigenin loaded gastroretentive microsponge for the targeting of Helicobacter pylori

Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro

“…The FT-IR spectra of AP, AP-NLC, GMS, and blank NLC are shown in Figure 8 . The strong bands generated by the valence vibration of the hydroxyl group (-OH) at 3292 cm −1 , the stretching vibrations of the carbonyl group (C=O) at 1653 cm −1 and 1608 cm −1 , and the stretching vibration of the pyran ring (C-O-C) at 1355 cm −1 were classified as the characteristic absorption peaks of AP [ 30 ]. The absorption peaks of GMS at 3316 cm −1 , 2914 cm −1 , 2851 cm −1 , and 1731 cm −1 were derived from the stretching vibration of -OH, -CH, -CH2-, and C=O [ 31 , 32 , 33 ].…”

“…The fluctuation of EE% and DL% caused by changing the solid-liquid lipid ratio was coherent. Therefore, it was finally determined that the emulsifier dosage (1-2), lipid-drug ratio (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and solid-liquid lipid ratio (3)(4)(5)(6)(7)(8) were set as the three experimental design factors as well as the high and low levels for CCD-RSM. According to Table 2, primary items A and C, interactive items AB and AC, and secondary items A 2 , B 2 , and C 2 have a very significant impact on EE% (p < 0.05), while other factors have no significant impact.…”

“…Molecules 2023, 26, x FOR PEER REVIEW 9 of 20 vibration of the hydroxyl group (-OH) at 3292 cm −1 , the stretching vibrations of the carbonyl group (C=O) at 1653 cm −1 and 1608 cm −1 , and the stretching vibration of the pyran ring (C-O-C) at 1355 cm −1 were classified as the characteristic absorption peaks of AP [30].…”

“…vibration of the hydroxyl group (-OH) at 3292 cm , the stretching vibrations of the carbonyl group (C=O) at 1653 cm −1 and 1608 cm −1 , and the stretching vibration of the pyran ring (C-O-C) at 1355 cm −1 were classified as the characteristic absorption peaks of AP [30] The absorption peaks of GMS at 3316 cm −1 , 2914 cm −1 , 2851 cm −1 , and 1731 cm −1 were derived from the stretching vibration of -OH, -CH, -CH2-, and C=O [31][32][33]. The characteristic peak of AP does not appear in the spectrum of AP-NLC but is highly consistent with the peak position of GMS and the spectrum of blank NLC.…”

“…Various concentrations (10,20,30,40,50, 60 µmol/L) of AP and AP-NLC were cocultured with NCI-H1299 cells for 24, 48, and 72 h, respectively, and other operations were performed as in Section 3.11.1.…”