Development of asymptomatic primary biliary cirrhosis in a patient with Hashimoto's thyroiditis and improvement of the liver disease by treatment of the thyroiditis.

Miki, Takuji; Sakane, Tsuyoshi; Takada, S; Yamauchi, Yasutaka; Takemoto, Tsunematsu; Hirakawa, Hiroyasu; Nagaoka, Saburo

doi:10.2169/naika.77.524

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The mechanisms underlying the differences be tween the clinical courses are not known. However, the findings in the present patient and the case reported by Miki et al (14) indicate the possible inhibitory effect of thyroid drugs on the progression of PBC.…”

Section: Sasaki Et Al (1) Investigated 180 Cases Of Pbc Andcontrasting

confidence: 63%

“…Miki et al (14) reported that replacement therapy for reduced thyroid function in Hashimoto's thyroiditis with PBC led to an improvement in abnormal findings related to PBC in addition to improvement in thyroid function. Although the mechanisms responsible for this improvement are unclear, a recent experimental study revealed that thyroid function may influence bile flow.…”

Section: Sasaki Et Al (1) Investigated 180 Cases Of Pbc Andmentioning

confidence: 99%

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A Case of Primary Biliary Cirrhosis Associated with Hashimoto's Thyroiditis, Scleroderma and Sjoegren's Syndrome.

et al. 1992

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A 53-year-old woman was admitted because of Raynaud's phenomenon, polyarthralgia and polymyalgia. Biopsy specimens of the liver and thyroid gland revealed characteristic findings of primary biliary cirrhosis (PBC) (stage I by Scheuer's classification) and chronic thyroiditis. Her clinical features were also complicated by scleroderma (type I by Barnett's classification) and Sjogren's syndrome (Sjs) with keratoconjunctivitis sicca. Thyroid hormone replacement therapy led to improvement in thyroid function, normalization of the biliary tract enzymes and alleviation of subjective symptoms. (Internal Medicine 32: 418-421, 1992)

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Section: Sasaki Et Al (1) Investigated 180 Cases Of Pbc Andcontrasting

confidence: 63%

Section: Sasaki Et Al (1) Investigated 180 Cases Of Pbc Andmentioning

confidence: 99%

A Case of Primary Biliary Cirrhosis Associated with Hashimoto's Thyroiditis, Scleroderma and Sjoegren's Syndrome.

et al. 1992

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Acquired factor V inhibitor complicated by Hashimoto's thyroditis, primary biliary cirrhosis and membranous nephropathy

Takahashi¹,

Fuse

Abe³

et al. 2003

Blood Coagulation & Fibrinolysis

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A 59-year-old man diagnosed as having Hashimoto's thyroditis, primary biliary cirrhosis (PBC) and membranous nephropathy (MN) showed consciousness disturbance, convulsions of the upper part of his body, and rapid progression of anemia, which seemed to be derived from subdural and retroperitoneal hemorrhage, respectively. He had been diagnosed as having eosinophilia about 6 weeks before the attack. Coagulation tests revealed a prolonged activated partial thromboplastin time and prothrombin time, which could not be normalized by mixing with normal plasma. Factor V (FV) activity was severely decreased and the purified immunoglobulin G of the patient inhibited normal plasma FV activity in a dose-dependent manner, suggesting the presence of antibody-mediated circulating inhibitors specific for FV. Treatment with steroids and azathioprine as well as plasmapheresis led to improvement of his clinical symptoms, normalization of the coagulation tests, and disappearance of eosinophilia. However, the inhibitor reappeared about 7 months later in association with eosinophilia, which was also improved by steroid therapy. To our knowledge, this is the first report of the co-existence of these three kinds of immune-mediated disorders, and the first report concerning the association between acquired FV inhibitors and PBC with MN. A new unknown immune mechanism, which causes eosinophilia, may be involved in the development of the FV inhibitor in this patient.

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Development of asymptomatic primary biliary cirrhosis in a patient with Hashimoto's thyroiditis and improvement of the liver disease by treatment of the thyroiditis.

Cited by 2 publications

References 6 publications

A Case of Primary Biliary Cirrhosis Associated with Hashimoto's Thyroiditis, Scleroderma and Sjoegren's Syndrome.

A Case of Primary Biliary Cirrhosis Associated with Hashimoto's Thyroiditis, Scleroderma and Sjoegren's Syndrome.

Acquired factor V inhibitor complicated by Hashimoto's thyroditis, primary biliary cirrhosis and membranous nephropathy

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