Development of atopic disease in relation to family history and cord blood IgE levels

Croner, S.; Kjetlman, N. I. M.

doi:10.1111/j.1399-3038.1990.tb00003.x

Cited by 142 publications

(89 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies are essen tially based on the use of lymphoprolifération assays, and only limited information is available on relevant T cell cyto kine responses over this age range. In particular, despite in-direct evidence of low-level fetal IgE synthesis [11] and of spontaneous production of high levels of Th2 cytokines by the fetoplacental unit throughout gestation [12], there is as yet no published evidence of allergen-speeific Th2 cytokine responses by human neonatal lymphocytes.…”

mentioning

confidence: 99%

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

Prescott

Macaubas

Yabuhara

et al. 1997

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Several recent studies have demonstrated cord blood mononuclear cell (CBMC) proliferation in response to food and inhalant allergens, suggesting that initial T-cell-priming may occur in utero. The findings below from an ongoing prospective study on 60 subjects provide initial information on the nature of accompanying T cell cytokine responses. We demonstrate CBMC proliferation following culture with house dust mite and ovalbumin (OVA) in 47 and 42% of subjects, respectively, compared to an overall rate of 3% for tetanus toxoid; the frequencies of these responses were comparable in neonates with and without atopic family history (FH). With the exception of IL-10, analysis of cytokine responses in allergen-stimulated cultures of CBMCs required the use of semiquantitative RT-PCR, which revealed low-level IL-4 and/or IL-5 mRNA production, in particular a 50% IL-5 response rate to OVA in FH-positive neonates. IFN-γ responses were less frequent and required higher PCR cycle numbers for detection. Preliminary analysis of culture supernatants from a subgroup of CBMCs indicate high-level allergen-specific IL-10 responses in both FH-negative and -positive subjects, detectable by ELISA. Parallel PCR studies on MCs from 27 children (mean age 18 months) indicated a clear segregation at this age on the basis of FH, with Th0-like or mixed Th1/Th2 responses (IL-5 plus IFN-γ) which were mainly restricted to the FH-positive group.

show abstract

mentioning

confidence: 99%

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

Prescott

Macaubas

Yabuhara

et al. 1997

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Several studies indicate that the prevalence of allergy is increasing, particularly in countries with a ''western lifestyle'' (1)(2)(3)(4)(5)(6). All of these studies were related to eczema or respiratory allergy, however.…”

mentioning

confidence: 99%

“…All of these studies were related to eczema or respiratory allergy, however. Less is known regarding the epidemiology of adverse reactions to food although such reactions are the major manifestations of allergy in infants and toddlers (6). A prospective study in Iceland yielded a prevalence of food allergy below 2% (Ardal, unpublished results).…”

mentioning

confidence: 99%

Adverse reactions to food and food allergy in young children in Iceland and Sweden

Kristjansson

Árdal

Jónsson

et al. 1999

Scandinavian Journal of Primary Health Care

View full text Add to dashboard Cite

“…The possibility of the relationship between specific sensitization and cat ownership being influenced by families with atopic history keeping pets less frequently needs to be considered. However, this issue should not influence the results of the present study since it is repeatedly observed that in absolute numbers the majority of atopic patients do not come from families with a positive history but from "normal" parents [18,19].…”

Section: Discussionmentioning

confidence: 79%

Cat sensitivity: 7-yr audit in children attending a paediatric allergy clinic in North Italy

Pescollderungg¹,

Pietrobelli²,

Boner³

2000

Eur Respir J

View full text Add to dashboard Cite

Sensitivity to cats and exposure to cat allergen is a common cause of asthma exacerbation in children. To date, there is no data on the prevalence of cat sensitivity in children living in North Italy. Therefore, a 7-yr survey was performed in patients attending an allergy clinic for the first time.Skin prick tests (SPT) for perennial allergens and for pollens relevant to the region were performed in 4,957 children attending the outpatient clinic 1992±1998. A questionnaire on present or past cat ownership was presented to all cat-skin prick test positive children. An evaluation of cat ownership on the general population was made by telephone interview on a random sample of 1,268 families living in the same area.With a 3-mm wheal as a positive cut-off 439 (8.85%) children had a positive SPT to cats. Of these 103 (23.4%) had a cat at home and 336 (76.6%) never had a cat in the house. With a greater positive cut-off (a wheal diameter $4 mm) 140 (2.8%) showed a positive SPT to cats of these 35 (25%) had a cat at home and 105 (75%) had only an indirect exposure to the pet. Of the telephone interviewed families; 16% stated they had a cat at home.Cat sensitivity is less prevalent in Italy, in this hospital based population, compared with other European countries and this is in agreement with a lower rate of cat ownership. Cat sensitivity was three times more frequent in children who never had a cat at home, than in children living with cats, when the selected positive cut-off was either a wheal diameter of 3 mm or $4 mm. Thus in a population with a low prevalence of cat ownership public exposure seems to be more important than domestic exposure for the development of sensitivity. Eur Respir J 2000; 16: 857±860. Allergy to indoor allergens (house dust mites, domestic pets and cockroaches) is a major cause of ill health in children. In the USA, cat and dog allergens sensitivity has been shown to occur in up to 67% of asthmatic children in settings where they are the dominant indoor allergens [1,2]. In the UK, pet ownership is very common and approximately one-third of homes have a cat and one-quarter a dog [3]. Pets are the second most important cause of allergy in the domestic environment in the UK, and up to 40% of asthmatic children are sensitized to cat and/or dog allergens [4]. In a population survey in Northern Sweden cat and dog allergens elicited the greatest number of positive skin test responses; the proportion of children sensitized against cats was 13.4% and dogs 8.7% [5]. Furthermore, sensitization to cat allergen is common among asthmatic children in Japan where cat-specific immunoglobulin E (IgE) were found in sera of 70% of asthmatic children who kept cats and 34% of patients who had never kept cats at home [6]. In the German Multicenter Atopy Study cumulative rates of sensitization to cat antigen dI (Fel dI) among children with a family history of atopy were 5±6% in the first 3 yrs of life [7].Since no data on the prevalence of cat sensitivity in children is available from North Italy, the preva...

show abstract

Development of atopic disease in relation to family history and cord blood IgE levels

Cited by 142 publications

References 24 publications

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

Adverse reactions to food and food allergy in young children in Iceland and Sweden

Cat sensitivity: 7-yr audit in children attending a paediatric allergy clinic in North Italy

Contact Info

Product

Resources

About