Development of attentional networks: An fMRI study with children and adults

Konrad, Kerstin; Neufang, Susanne; Thiel, Christiane M.; Specht, Karsten; Hanisch, Charlotte; Fan, Jin; Herpertz‐Dahlmann, Beate; Fink, Gereon R.

doi:10.1016/j.neuroimage.2005.06.065

Cited by 312 publications

(280 citation statements)

References 50 publications

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“…When activated by sudden changes in the subject's environment, ACC may operate as a ''supervisory attentional system,'' able to promote the activity of the dorsolateral PFC for the integration of plans, instructions, stimulus processing, decision making, short-term memory updating, and response control [Shallice, 1988]. In this sense, the present results extend previous evidence suggesting that the directed attention is organized at the level of a distributed large-scale network revolving around three cortical epicentres (or local networks)-ACC, dorsolateral PFC, and posterior parietal cortex [Mesulam, 1981[Mesulam, , 1990[Mesulam, , 1999Nebel et al, 2005], which would provide a slightly different but interactive and complementary type of top-down attentional functions [Corbetta and Shulman, 2002;Fan et al, 2005;Kondo et al, 2004;Konrad et al, 2005;Luks et al, 2002;MacDonald et al, 2000;Milham et al, 2003].…”

Section: Discussionsupporting

confidence: 83%

Directional functional coupling of cerebral rhythms between anterior cingulate and dorsolateral prefrontal areas during rare stimuli: A directed transfer function analysis of human depth EEG signal

Brázdil

Babiloni

Román

et al. 2007

Human Brain Mapping

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Abstract:What is the neural substrate of our capability to properly react to changes in the environment? It can be hypothesized that the anterior cingulate cortex (ACC) manages repetitive stimuli in routine conditions and alerts the dorsolateral prefrontal cortex (PFC) when stimulation unexpectedly changes. To provide evidence in favor of this hypothesis, intracerebral stereoelectroencephalographic (SEEG) data were recorded from the anterior cingulate and dorsolateral PFC of eight epileptic patients in a standard visual oddball task during presurgical monitoring. Two types of stimuli (200 ms duration) such as the letters O (frequent stimuli; 80% of probability) and X (rare stimuli) were presented in random order, with an interstimulus interval between 2 and 5 s. Subjects had to mentally count the rare (target) stimuli and to press a button with their dominant hand as quickly and accurately as possible. EEG frequency bands of interest were y (4-8 Hz), a (8-12 Hz), b (14-30 Hz), and g (30-45 Hz). The directionality of the information flux within the EEG rhythms was indexed by a directed transfer function (DTF). The results showed that compared with the frequent stimuli, the target stimuli induced a statistically significant increase of DTF values from the anterior cingulate to the dorsolateral PFC at the y rhythms (P < 0.01). These results provide support to the hypothesis that ACC directly or indirectly affects the oscillatory activity of dorsolateral PFC by a selective frequency code under typical oddball conditions. Hum Brain

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Section: Discussionsupporting

confidence: 83%

Directional functional coupling of cerebral rhythms between anterior cingulate and dorsolateral prefrontal areas during rare stimuli: A directed transfer function analysis of human depth EEG signal

Brázdil

Babiloni

Román

et al. 2007

Human Brain Mapping

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“…Third, the change toward a level of prefrontal activation similar to that for HCs after the 4-to-8-week open trial (Figure 4c) is consistent with the results from a fMRI study of adults with ADHD (Bush et al, 2008) and an ERP study in children with ADHD (Sawada et al, 2010). Finally, our finding (Figure 4d) that long-term (1 year) MPH treatment affected brain development in ADHD children is consistent with the findings of a prospective MRI study (Konrad et al, 2007).…”

Section: Discussionsupporting

confidence: 88%

Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Ishii-Takahashi

Takizawa

Nishimura

et al. 2015

Neuropsychopharmacol

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Although methylphenidate hydrochloride (MPH) is a first-line treatment for children with attention-deficit hyperactivity disorder (ADHD), the non-response rate is 30%. Our aim was to develop a supplementary neuroimaging biomarker for predicting the clinical effect of continuous MPH administration by using near-infrared spectroscopy (NIRS). After baseline assessment, we performed a double-blind, placebo-controlled, crossover trial with a single dose of MPH, followed by a prospective 4-to-8-week open trial with continuous MPH administration, and an ancillary 1-year follow-up. Twenty-two drug-naïve and eight previously treated children with ADHD (NAÏVE and NON-NAÏVE) were compared with 20 healthy controls (HCs) who underwent multiple NIRS measurements without intervention. We tested whether NIRS signals at the baseline assessment or ΔNIRS (single dose of MPH minus baseline assessment) predict the Clinical Global Impressions-Severity (CGI-S) score after 4-to-8-week or 1-year MPH administration. The secondary outcomes were the effect of MPH on NIRS signals after single-dose, 4-to-8-week, and 1-year administration. ΔNIRS significantly predicted CGI-S after 4-to-8-week MPH administration. The leave-one-out classification algorithm had 81% accuracy using the NIRS signal. ΔNIRS also significantly predicted CGI-S scores after 1 year of MPH administration. For secondary analyses, NAÏVE exhibited significantly lower prefrontal activation than HCs at the baseline assessment, whereas NON-NAÏVE and HCs showed similar activation. A single dose of MPH significantly increased activation compared with the placebo in NAÏVE. After 4-to-8-week administration, and even after MPH washout following 1-year administration, NAÏVE demonstrated normalized prefrontal activation. Supplementary NIRS measurements may serve as an objective biomarker for clinical decisions and monitoring concerning continuous MPH treatment in children with ADHD.

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“…12 Such variability is likely to arise secondary to the normal maturation of frontoparietal networks underlying spatial working memory from childhood to adolescence. 33,34 Nonetheless, the task was highly sensitive in terms of functional brain imaging. All children were clearly engaged in the task, performing above chance level, and fMRI consequently revealed significant activation patterns associated with this task performance.…”

Section: Discussionmentioning

confidence: 99%

Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study

et al. 2007

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Attention deficit hyperactivity disorder, combined type (ADHD-CT) is associated with spatial working memory deficits. These deficits are known to be subserved by dysfunction of neural circuits involving right prefrontal, striatal and parietal brain regions. This study determines whether decreased right prefrontal, striatal and parietal activation with a mental rotation task shown in adolescents with ADHD-CT is also evident in children with ADHD-CT. A crosssectional study of 12 pre-pubertal, right-handed, 8-12-year-old boys with ADHD-CT and 12 prepubertal, right-handed, performance IQ-matched, 8-12-year-old healthy boys, recruited from local primary schools, was completed. Participants underwent functional magnetic resonance imaging while performing a mental rotation task that requires spatial working memory. The two groups did not differ in their accuracy or response times for the mental rotation task. The ADHD-CT group showed significantly less activation in right parieto-occipital areas (cuneus and precuneus, BA 19), the right inferior parietal lobe (BA 40) and the right caudate nucleus. Our findings with a child cohort confirm previous reports of right striatal-parietal dysfunction in adolescents with ADHD-CT. This dysfunction suggests a widespread maturational deficit that may be developmental stage independent.

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Development of attentional networks: An fMRI study with children and adults

Cited by 312 publications

References 50 publications

Directional functional coupling of cerebral rhythms between anterior cingulate and dorsolateral prefrontal areas during rare stimuli: A directed transfer function analysis of human depth EEG signal

Directional functional coupling of cerebral rhythms between anterior cingulate and dorsolateral prefrontal areas during rare stimuli: A directed transfer function analysis of human depth EEG signal

Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial

Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study

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